XB-ART-4392
Neuroreport
2003 Dec 02;1417:2163-6. doi: 10.1097/00001756-200312020-00006.
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The Xenopus noggin promoter drives roof-plate specific transcription.
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During vertebrate neural development, inductive signals derived from the roof plate specify dorsal neural cell types of spinal cord as well as adjacent dermomytotome. Noggin has been demonstrated to play a pivotal role in this signaling network but how its expression is regulated remains unclear. To investigate this issue, we identified a 2066 bp Xenopus noggin 5' flanking sequence which recapitulates the roof-plate expression of endogenous gene in transgenic frog tadpoles and we further mapped the roof-plate enhancer to a sequence as short as 79 bp. Our results, therefore, not only shed light on but also provide a powerful tool to the study of neural and somite patterning.
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Species referenced: Xenopus laevis
Genes referenced: nog