Prog Clin Biol Res 1987 Jan 01;233:129-40.

Compromised T-cell regulatory functions during anuran metamorphosis: the role of corticosteroids.

Abstract
Glucocorticoid receptor concentrations, which are undetectable before metamorphosis, increase to a maximum during the metamorphic period and decline to toadlet levels thereafter. The generation of a high concentration of receptors, imparting enhanced glucocorticoid sensitivity particularly to the lymphoid tissues of metamorphic larvae suggests the possibility that increasing endogenous levels could be responsible for the compromised T-cell functions which have been described for these stages of development (Ruben et al, 1985a).

PubMed ID: 2954165

Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: tbx2