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XB-ART-27141
FEBS Lett 1988 Dec 05;2411-2:119-25.
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Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling.

Kubo T , Bujo H , Akiba I , Nakai J , Mishina M , Numa S .


Abstract
Chimaeric muscarinic acetylcholine receptors (mAChR) in which corresponding portions of mAChR I and mAChR II are replaced with each other have been produced in Xenopus oocytes by expression of cDNA constructs encoding them. Functional analysis of the chimaeric mAChRs indicates that a region mostly comprising the putative cytoplasmic portion between the proposed transmembrane segments V and VI is involved in selective coupling of mAChR I and mAChR II with different effector systems. In contrast, the exchange of this region between mAChR I and mAChR II does not significantly affect the antagonist binding properties of the two mAChR subtypes.

PubMed ID: 3197827
Article link: FEBS Lett