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XB-ART-29885
Proc Natl Acad Sci U S A 1984 Jan 01;811:160-4.
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Perpendicular orientation and directional migration of amphibian neural crest cells in dc electrical fields.

Cooper MS , Keller RE .


Abstract
The behavior of cultured neural crest cells of Ambystoma mexicanum and Xenopus laevis in dc electrical fields was studied. In fields of 1-5 V/cm, isolated or confluent cells retract both their anode- and cathode-facing margins. Subsequently, the cells elongate, with protrusive activity confined to their narrow ends. In larger fields (greater than or equal to 5 V/cm), protrusions form on the cathode-facing sides of the perpendicularly oriented cells. The cells then begin migrating laterally, perpendicular to their long axes, towards the cathode. We suggest that the perpendicular alignment and cathode-directed migrations result from cytoskeletal changes mediated by modified ion fluxes through the anode-facing (hyperpolarized) and cathode-facing (depolarized) cell membranes. The breaking of cellular confluence in response to dc electric fields is also discussed.

PubMed ID: 6582473
PMC ID: PMC344630
Article link: Proc Natl Acad Sci U S A
Grant support: [+]


References [+] :
Barker, The glabrous epidermis of cavies contains a powerful battery. 1982, Pubmed