Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-1174
Dev Cell 2005 Nov 01;95:593-603. doi: 10.1016/j.devcel.2005.09.016.
Show Gene links Show Anatomy links

SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation.

Taylor KM , Labonne C .


???displayArticle.abstract???
Sox9 and the closely related factor Sox10 are essential for the formation of neural crest precursor cells, and play divergent roles in the process by which these cells are subsequently directed to form specific derivatives. These group E Sox factors have also been implicated in the development of the vertebrate inner ear. Despite their importance, however, the mechanisms that allow SoxE proteins to regulate such a diverse range of cell types have remained poorly understood. Here we demonstrate that during vertebrate development, the activities of individual SoxE factors are well conserved and are regulated by SUMOylation. We show that SoxE mutants that cannot be SUMOylated, or that mimic constitutive SUMOylation, are each able to mediate a subset of the diverse activities characteristic of wild-type SoxE proteins. These findings provide important mechanistic insight into how the activity of widely deployed developmental regulatory proteins can be directed to specific developmental events.

???displayArticle.pubmedLink??? 16256735
???displayArticle.link??? Dev Cell


Species referenced: Xenopus
Genes referenced: dlx3 foxd3 gal.2 myc pax8 snai2 sox10 sox9 ube2i
???displayArticle.morpholinos??? sox10 MO1


???attribute.lit??? ???displayArticles.show???