Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-25259
Ciba Found Symp 1991 Jan 01;162:165-76; discussion 176-81. doi: 10.1002/9780470514160.ch10.
Show Gene links Show Anatomy links

Development of the left-right axis in amphibians.

Yost HJ .


???displayArticle.abstract???
The heart and viscera of vertebrates are formed from primordia that are apparently bilaterally symmetrical. This symmetry is broken during development, yielding organs that develop characteristic asymmetries along the left-right axis. Results from three lines of experimentation on embryos of the amphibian Xenopus laevis indicate that left-right asymmetries are established early in development and that cellular interactions transmit left-right information from one primordium to another. First, a cytoplasmic rearrangement that occurs during the first cell cycle after fertilization may establish left-right asymmetry in some regions of the embryo. Second, a variety of experimental results indicate that embryonic ectoderm or its basal extracellular matrix may transmit left-right axial information to cardiac mesoderm and visceral endoderm. Third, inhibition of proteoglycan synthesis during a narrow period of development, concurrent with the migration of the cardiac primordia to the ventral midline, prevents asymmetrical development of the heart.

???displayArticle.pubmedLink??? 1802642
???displayArticle.link??? Ciba Found Symp
???displayArticle.grants??? [+]