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Temperature dependence of gating current in myelinated nerve fibers.
Jonas P
.
Abstract
Asymmetrical displacement currents and Na currents of single myelinated nerve fibers of Xenopus laevis were studied in the temperature range from 5 to 24 degrees C. The time constant of the on-response at E = 4 mV, tau on, was strongly temperature dependent, whereas the amount of displaced charge at E = 39 mV, Qon, was only slightly temperature dependent. The mean Q10 for tau on-1 was 2.54, the mean Q10 for Qon was 1.07. The time constant of charge immobilization, tau i, at E = 4 mV varied significantly (alpha = 0.001) with temperature. The mean Q10 for tau i-1 was 2.71 +/- 0.38. The time constants of immobilization of gating charge and of fast inactivation of Na permeability were similar in the temperature range from 6 to 22 degrees C. The Qoff/Qon ratio for E = 4 mV pulses of 0.5 msec duration decreased with increasing temperature. The temperature dependence of the time constant of the off-response could not be described by a single Q10 value, since the Q10 depended on the duration of the test pulse. Increasing temperature shifted Qon (E) curves to more negative potentials by 0.51 mV K-1, but shifted PNa (E) curves and h infinity (E) curves to more positive potentials by 0.43 and 0.57 mV K-1, respectively. h infinity (E = -70 mV) increased monotonously with increasing temperature. The present data indicate that considerable entropy changes may occur when the Na channel molecule passes from closed through open to inactivated states.
Almers,
Gating currents and charge movements in excitable membranes.
1978, Pubmed
Almers,
Gating currents and charge movements in excitable membranes.
1978,
Pubmed
Armstrong,
Fast and slow steps in the activation of sodium channels.
1979,
Pubmed
Armstrong,
Currents related to movement of the gating particles of the sodium channels.
1973,
Pubmed
Armstrong,
Inactivation of the sodium channel. II. Gating current experiments.
1977,
Pubmed
Baumann,
The equilibrium between metarhodopsin I and metarhodopsin II in the isolated frog retina.
1978,
Pubmed
Bezanilla,
Temperature effects on gating currents in the squid giant axon.
1978,
Pubmed
Chiu,
Anomalous temperature dependence of the sodium conductance in rabbit nerve compared with frog nerve.
1979,
Pubmed
Collins,
Temperature dependence of the sodium channel gating kinetics in the node of Ranvier.
1982,
Pubmed
,
Xenbase
Conti,
Pressure dependence of the sodium currents of squid giant axon.
1982,
Pubmed
Conti,
Pressure dependence of sodium gating currents in the squid giant axon.
1984,
Pubmed
Drouin,
Specific and unspecific charges at the sodium channels of the nerve membrane.
1974,
Pubmed
Dubois,
Kinetics of intramembrane charge movement and sodium current in frog node of Ranvier.
1982,
Pubmed
Dudel,
Voltage and time dependence of excitatory sodium current in cooled sheep Purkinje fibres.
1970,
Pubmed
Edmonds,
A comparison of sodium channel kinetics in the squid axon, the frog node and the frog node with BTX using the "silent gate" model.
1987,
Pubmed
FRANKENHAEUSER,
THE EFFECT OF TEMPERATURE ON THE SODIUM AND POTASSIUM PERMEABILITY CHANGES IN MYELINATED NERVE FIBRES OF XENOPUS LAEVIS.
1963,
Pubmed
,
Xenbase
GRAHAME,
The electrical double layer and the theory of electrocapillarity.
1947,
Pubmed
Horn,
Statistical properties of single sodium channels.
1984,
Pubmed
Howarth,
Heat production non-myelinated nerves.
1975,
Pubmed
Jennrich,
Fitting nonlinear models to data.
1979,
Pubmed
Kimura,
The effect of temperature on the asymmetrical charge movement in squid giant axons.
1979,
Pubmed
Kniffki,
Development of sodium permeability inactivation in nodal membranes.
1981,
Pubmed
,
Xenbase
Matteson,
Evidence for a population of sleepy sodium channels in squid axon at low temperature.
1982,
Pubmed
Meves,
Inactivation of the asymmetrical displacement current in giant axons of Loligo forbesi.
1977,
Pubmed
Neumcke,
Asymmetrical displacement current and its relation with the activation of sodium current in the membrane of frog myelinated nerve.
1976,
Pubmed
Nonner,
Effects of Leiurus scorpion venom on the "gating" current in myelinated nerve.
1979,
Pubmed
Nonner,
Asymmetrical displacement currents in the membrane of frog myelinated nerve: early time course and effects of membrane potential.
1978,
Pubmed
Nonner,
A new voltage clamp method for Ranvier nodes.
1969,
Pubmed
Nonner,
Displacement currents in the node of Ranvier. Voltage and time dependence.
1975,
Pubmed
Nonner,
Relations between the inactivation of sodium channels and the immobilization of gating charge in frog myelinated nerve.
1980,
Pubmed
Pfeil,
Thermodynamic investigations of proteins. III. Thermodynamic description of lysozyme.
1976,
Pubmed
Schauf,
Modifications of sodium channel gating in Myxicola giant axons by deuterium oxide, temperature, and internal cations.
1979,
Pubmed
Schwarz,
The effect of temperature on Na currents in rat myelinated nerve fibres.
1986,
Pubmed
Schwarz,
Temperature experiments on nerve and muscle membranes of frogs. Indications for a phase transition.
1979,
Pubmed
Tanguy,
Batrachotoxin uncouples gating charge immobilization from fast Na inactivation in squid giant axons.
1988,
Pubmed
Tsien,
A transition state theory approach to the kinetics of conductance changes in excitable membranes.
1969,
Pubmed
Vogel,
Calcium and lanthanum effects at the nodal membrane.
1974,
Pubmed
,
Xenbase