XB-ART-49744
Environ Toxicol Pharmacol
2014 Jul 01;381:153-62. doi: 10.1016/j.etap.2014.05.010.
Show Gene links
Show Anatomy links
Effects of antagonist of retinoid X receptor (UVI3003) on morphology and gene profile of Xenopus tropicalis embryos.
???displayArticle.abstract???
We exposed Xenopus tropicalis embryos to a selective antagonist of retinoid X receptor (UVI3003). UVI3003 induced multiple malformations at the concentrations of 200-1000 μg/L after 48 h exposure. The most prominent malformations affected brains, eyes, cement gland and fins. UVI3003 also induced variable and divergent malformations at 250-1500 μg/L after 0-24 and 24-48 h exposure. Microarray analysis showed that seven genes (rps15, serp2, fmr1, cyp2e1, lrrc9, ugtla6 and LOC100490188) were differentially regulated in all three treatment groups after 0-24h exposure. The most significantly affected pathway was galactose metabolism. In 24-48 h exposure groups, 18 genes were differentially regulated, mainly comprising components of the PPAR signaling pathway. These results suggested that UVI3003 is teratogenic in amphibian embryos. Differential gene expression suggests that galactose metabolism and PPAR signaling pathways may provide underlying mechanistic detail accounting for the observed malformations.
???displayArticle.pubmedLink??? 24950139
???displayArticle.link??? Environ Toxicol Pharmacol
Species referenced: Xenopus tropicalis
Genes referenced: cyp2e1.2 fmr1 lrrc9 rps15 serp2