Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-55395
Biol Pharm Bull 2018 Jan 01;418:1295-1298. doi: 10.1248/bpb.b18-00250.
Show Gene links Show Anatomy links

Direct Activation of the Large-Conductance Calcium-Activated Potassium Channel by Flavonoids Isolated from Sophora flavescens.

Lee S , Choi JS , Park CS .


Abstract
In our recent study, we reported that kurarinone, one of the most abundant flavonoids found in the dry root of Sophora flavescens (Kushen), is a potent activator of the large-conductance Ca2+-activated K+ (BKCa) channel. Herein, we isolated and characterized other flavonoid components from Kushen. Among the 13 compounds tested, six flavonoids were found to activate the BKCa channel, three of which, 7,4'-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone, kuraridin, and kuraridinol, are new activators of the BKCa channel.

PubMed ID: 30068881
Article link: Biol Pharm Bull