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EMBO J
1986 Aug 01;58:1973-80. doi: 10.1002/j.1460-2075.1986.tb04452.x.
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A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus.
Duboule D
,
Baron A
,
Mähl P
,
Galliot B
.
Abstract
A new murine homeo-box (Hox1-3) has been isolated and studied with respect to its structure and transcriptional pattern. This homeo-box is part of a gene which is specifically regulated during mouse prenatal development and expressed in a restricted number of teratocarcinoma tumours as well as in adult testis. Hox1-3 is shown to be a member of a cluster of at least four homeo-boxes lying within a 75-kb segment of DNA on mouse chromosome 6. The structure of the whole cluster, the Hox-1 locus is presented.
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