XB-ART-36964
Biol Reprod
2008 Apr 01;784:726-35. doi: 10.1095/biolreprod.107.063693.
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Ca2+ homeostasis regulates Xenopus oocyte maturation.
Sun L
,
Hodeify R
,
Haun S
,
Charlesworth A
,
MacNicol AM
,
Ponnappan S
,
Ponnappan U
,
Prigent C
,
Machaca K
.
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In contrast to the well-defined role of Ca2+ signals during mitosis, the contribution of Ca2+ signaling to meiosis progression is controversial, despite several decades of investigating the role of Ca2+ and its effectors in vertebrate oocyte maturation. We have previously shown that during Xenopus oocyte maturation, Ca2+ signals are dispensable for entry into meiosis and for germinal vesicle breakdown. However, normal Ca2+ homeostasis is essential for completion of meiosis I and extrusion of the first polar body. In this study, we test the contribution of several downstream effectors in mediating the Ca2+ effects during oocyte maturation. We show that calmodulin and calcium-calmodulin-dependent protein kinase II (CAMK2) are not critical downstream Ca2+ effectors during meiotic maturation. In contrast, accumulation of Aurora kinase A (AURKA) protein is disrupted in cells deprived of Ca2+ signals. Since AURKA is required for bipolar spindle formation, failure to accumulate AURKA may contribute to the defective spindle phenotype following Ca2+ deprivation. These findings argue that Ca2+ homeostasis is important in establishing the oocyte's competence to undergo maturation in preparation for fertilization and embryonic development.
???displayArticle.pubmedLink??? 18094360
???displayArticle.pmcLink??? PMC2587222
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???displayArticle.grants??? [+]
AG13081 NIA NIH HHS , GM-61829 NIGMS NIH HHS , HD35688 NICHD NIH HHS , R01 GM061829-07 NIGMS NIH HHS , R01 GM061829-08 NIGMS NIH HHS , R01 HD035688-08A2 NICHD NIH HHS , RR20146 NCRR NIH HHS , R01 HD035688 NICHD NIH HHS
Species referenced: Xenopus
Genes referenced: aurka
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