Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Dev Biol
2007 Apr 01;3041:221-31. doi: 10.1016/j.ydbio.2006.12.024.
Show Gene links
Show Anatomy links
TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm.
diIorio P
,
Alexa K
,
Choe SK
,
Etheridge L
,
Sagerström CG
.
???displayArticle.abstract???
sonic hedgehog (shh) is expressed in anterior endoderm, where it is required to repress pancreas gene expression and to pattern the endoderm, but the pathway controlling endodermal shh expression is unclear. We find that expression of meis3, a TALE class homeodomain gene, coincides with shh expression in the endoderm of zebrafish embryos. Using a dominant negative construct or anti-sense morpholino oligos (MOs) to disrupt meis3 function, we observe ectopic insulin expression in anterior endoderm. This phenotype is also observed when meis3 MOs are targeted to the endoderm, suggesting that meis3 acts within the endoderm to restrict insulin expression. We also find that meis3 is required for endodermal shh expression, indicating that meis3 acts upstream of shh to restrict insulin expression. Loss of pbx4, a TALE gene encoding a Meis cofactor, produces the same phenotype as loss of meis3, consistent with Meis3 acting in a complex with Pbx4 as reported in other systems. Lastly, we observe a progressive anterior displacement of endoderm-derived organs upon disruption of meis3 or pbx4, apparently as a result of underdevelopment of the pharyngeal region. Our data indicate that meis3 and pbx4 regulate shh expression in anterior endoderm, thereby influencing patterning and growth of the foregut.
Akimenko,
Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head.
1994, Pubmed
Akimenko,
Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head.
1994,
Pubmed
Alexander,
A molecular pathway leading to endoderm formation in zebrafish.
1999,
Pubmed
Asahara,
Pbx-Hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner.
1999,
Pubmed
Azcoitia,
The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo.
2005,
Pubmed
Brendolan,
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.
2005,
Pubmed
Chan,
The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein.
1994,
Pubmed
Chen,
Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.
2001,
Pubmed
Choe,
Paralog group 1 hox genes regulate rhombomere 5/6 expression of vhnf1, a repressor of rostral hindbrain fates, in a meis-dependent manner.
2004,
Pubmed
Choe,
Variable Meis-dependence among paralog group-1 Hox proteins.
2005,
Pubmed
Choe,
Meis family proteins are required for hindbrain development in the zebrafish.
2002,
Pubmed
Davidson,
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.
2003,
Pubmed
Deflorian,
Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation.
2004,
Pubmed
Dutta,
PDX:PBX complexes are required for normal proliferation of pancreatic cells during development.
2001,
Pubmed
Ferretti,
Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.
2006,
Pubmed
Field,
Formation of the digestive system in zebrafish. I. Liver morphogenesis.
2003,
Pubmed
Hebrok,
Hedgehog signaling in pancreas development.
2003,
Pubmed
Hebrok,
Notochord repression of endodermal Sonic hedgehog permits pancreas development.
1998,
Pubmed
Hebrok,
Regulation of pancreas development by hedgehog signaling.
2000,
Pubmed
Hisa,
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals.
2004,
Pubmed
Huang,
MEIS C termini harbor transcriptional activation domains that respond to cell signaling.
2005,
Pubmed
Jonsson,
Insulin-promoter-factor 1 is required for pancreas development in mice.
1994,
Pubmed
Kaczirek,
Nesidioblastosis: an old term and a new understanding.
2004,
Pubmed
Kikuchi,
casanova encodes a novel Sox-related protein necessary and sufficient for early endoderm formation in zebrafish.
2001,
Pubmed
Kim,
Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.
2002,
Pubmed
Kim,
Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor.
1998,
Pubmed
Kimmel,
Stages of embryonic development of the zebrafish.
1995,
Pubmed
,
Xenbase
Knoepfler,
A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1.
1999,
Pubmed
Kumar,
Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate.
2003,
Pubmed
Lachman,
Brief clinical report: a 46,XY phenotypic female with Smith-Lemli-Opitz syndrome.
1991,
Pubmed
Maeda,
Xpbx1b and Xmeis1b play a collaborative role in hindbrain and neural crest gene expression in Xenopus embryos.
2002,
Pubmed
,
Xenbase
Mann,
Hox proteins meet more partners.
1998,
Pubmed
Mercader,
Proximodistal identity during vertebrate limb regeneration is regulated by Meis homeodomain proteins.
2005,
Pubmed
Norton,
Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones.
2005,
Pubmed
Offield,
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.
1996,
Pubmed
,
Xenbase
Peers,
The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain.
1995,
Pubmed
Peltenburg,
Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx.
1996,
Pubmed
Porter,
Cholesterol modification of hedgehog signaling proteins in animal development.
1996,
Pubmed
Pöpperl,
lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish.
2000,
Pubmed
Roy,
Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo.
2001,
Pubmed
Sagerström,
Isolation and characterization of posteriorly restricted genes in the zebrafish gastrula.
2001,
Pubmed
Sagerström,
Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions.
1996,
Pubmed
Saleh,
Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases.
2000,
Pubmed
Selleri,
Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.
2001,
Pubmed
Stafford,
Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development.
2002,
Pubmed
Strähle,
Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos.
1993,
Pubmed
Strähle,
Vertebrate floor-plate specification: variations on common themes.
2004,
Pubmed
Sun,
vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain.
2001,
Pubmed
Swift,
An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).
1998,
Pubmed
,
Xenbase
Vlachakis,
A novel pbx family member expressed during early zebrafish embryogenesis forms trimeric complexes with Meis3 and Hoxb1b.
2000,
Pubmed
Waskiewicz,
Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning.
2001,
Pubmed
Waskiewicz,
Eliminating zebrafish pbx proteins reveals a hindbrain ground state.
2002,
Pubmed
Wolf,
The function of cholesterol in embryogenesis.
1999,
Pubmed
Yee,
Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell.
2001,
Pubmed
Zerucha,
Cloning and developmental expression of a zebrafish meis2 homeobox gene.
2001,
Pubmed
diIorio,
Sid4: A secreted vertebrate immunoglobulin protein with roles in zebrafish embryogenesis.
2005,
Pubmed
diIorio,
Sonic hedgehog is required early in pancreatic islet development.
2002,
Pubmed
van Dijk,
extradenticle raises the DNA binding specificity of homeotic selector gene products.
1994,
Pubmed
