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XB-ART-25136
Experientia 1991 Jan 15;471:64-6. doi: 10.1007/bf02041254.
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Kelletinin I and kelletinin A from the marine mollusc Buccinulum corneum are inhibitors of eukaryotic DNA polymerase alpha.

Orlando P , Carretta F , Grippo P , Cimino G , De Stefano S , Strazzullo G .


Abstract
The inhibitory effect of esters of p-hydroxybenzoic acid (kelletinins I and A), extracted from the marine gastropod Buccinulum corneum, have been tested on eukaryotic and prokaryotic enzymes of DNA metabolism such as DNA polymerases alpha and beta, DNA polymerase I, Exo III, pancreatic DNAse I, micrococcal DNAse and E. coli RNA polymerase. Kelletinin I and kelletinin A inhibit preferentially DNA polymerase alpha. The inhibitory effect of kelletinin I involves the hydroxyl group of p-hydroxybenzoic acid.

PubMed ID: 1999246
Article link: Experientia


Species referenced: Xenopus laevis
Genes referenced: pola1

References [+] :
Burgess, A new method for the large scale purification of Escherichia coli deoxyribonucleic acid-dependent ribonucleic acid polymerase. 1969, Pubmed