Cell 1980 Jul 01;203:859-64.

Does H-Y antigen induce the heterogametic ovary?

Abstract
To determine whether phylogenetically conservative H-Y antigen plays any part in gonadal differentiation among the nonmammalian vertebrates, we studied expression and binding of H-Y in the frog, Xenopus laevis. Soluble H-Y obtained from mouse testis and soluble H-W from chicken ovary bound specifically to cells of the ZZ testis from normal Xenopus males. In addition, H-Y (H-W) appeared selectively in the ovaries of ZZ genetic males that had been induced to become functional females by exposure to estradiol. Our observations suggest that H-Y (H-W) antigen may be involved in differentiation of the ZW ovary, and also that synthesis of H-Y may be regulated by sex steroids in the primitive ZW/ZZ species.

PubMed ID: 7191350
Article link: Cell


Species referenced: Xenopus laevis
Genes referenced: amh