Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
EMBO J
2000 Aug 01;1915:4036-45. doi: 10.1093/emboj/19.15.4036.
Show Gene links
Show Anatomy links
Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon.
Peretz A, Gil-Henn H, Sobko A, Shinder V, Attali B, Elson A.
???displayArticle.abstract???
Protein tyrosine phosphatase epsilon (PTP epsilon) is strongly expressed in the nervous system; however, little is known about its physiological role. We report that mice lacking PTP epsilon exhibit hypomyelination of sciatic nerve axons at an early post-natal age. This occurs together with increased activity of delayed- rectifier, voltage-gated potassium (Kv) channels and with hyperphosphorylation of Kv1.5 and Kv2.1 Kv channel alpha-subunits in sciatic nervetissue and in primary Schwann cells. PTP epsilon markedly reduces Kv1.5 or Kv2.1 current amplitudes in Xenopus oocytes. Kv2.1 associates with a substrate-trapping mutant of PTP epsilon, and PTP epsilon profoundly reduces Src- or Fyn-stimulated Kv2.1 currents and tyrosine phosphorylation in transfected HEK 293 cells. In all, PTP epsilon antagonizes activation of Kv channels by tyrosine kinases in vivo, and affects Schwann cell function during a critical period of Schwann cell growth and myelination.
Abitbol,
Stilbenes and fenamates rescue the loss of I(KS) channel function induced by an LQT5 mutation and other IsK mutants.
1999, Pubmed,
Xenbase
Abitbol,
Stilbenes and fenamates rescue the loss of I(KS) channel function induced by an LQT5 mutation and other IsK mutants.
1999,
Pubmed
,
Xenbase Bowlby,
Modulation of the Kv1.3 potassium channel by receptor tyrosine kinases.
1997,
Pubmed Decker,
Activation of a Ca2+-dependent K+ current by the oncogenic receptor protein tyrosine kinase v-Fms in mouse fibroblasts.
1998,
Pubmed Deng,
Fibroblast growth factor receptor 3 is a negative regulator of bone growth.
1996,
Pubmed den Hertog,
Protein-tyrosine phosphatases in development.
1999,
Pubmed Denu,
Protein tyrosine phosphatases: mechanisms of catalysis and regulation.
1998,
Pubmed Elson,
Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon.
1995,
Pubmed Elson,
Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu.
1995,
Pubmed Elson,
Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice.
1999,
Pubmed Fadool,
Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel.
1997,
Pubmed Fadool,
Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation.
1998,
Pubmed Fischer,
Cell signaling by protein tyrosine phosphorylation.
1999,
Pubmed Flint,
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.
1997,
Pubmed Guo,
bFGF promotes functional expression of transient outward currents in cultured neonatal rat ventricular cells.
1995,
Pubmed Holmes,
Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain.
1996,
Pubmed Huang,
Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor.
1993,
Pubmed
,
Xenbase Hunter,
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling.
1995,
Pubmed Huyer,
Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate.
1997,
Pubmed Jonas,
Insulin receptor in Aplysia neurons: characterization, molecular cloning, and modulation of ion currents.
1996,
Pubmed Jonas,
Regulation of potassium channels by protein kinases.
1996,
Pubmed Jurman,
Visual identification of individual transfected cells for electrophysiology using antibody-coated beads.
1994,
Pubmed Krueger,
Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.
1990,
Pubmed Levitan,
Modulation of ion channels by protein phosphorylation and dephosphorylation.
1994,
Pubmed Levitan,
Modulation of ion channels by protein phosphorylation. How the brain works.
1999,
Pubmed MacFarlane,
Changes in ion channel expression accompany cell cycle progression of spinal cord astrocytes.
2000,
Pubmed Mauro,
'Zip codes' direct intracellular protein tyrosine phosphatases to the correct cellular 'address'.
1994,
Pubmed Møller,
Selective down-regulation of the insulin receptor signal by protein-tyrosine phosphatases alpha and epsilon.
1995,
Pubmed Mukouyama,
Induction of protein tyrosine phosphatase epsilon transcripts during NGF-induced neuronal differentiation of PC12D cells and during the development of the cerebellum.
1997,
Pubmed Nakamura,
Molecular cloning of a novel cytoplasmic protein tyrosine phosphatase PTP epsilon.
1996,
Pubmed Neel,
Protein tyrosine phosphatases in signal transduction.
1997,
Pubmed Parsons,
Phosphatases and tumorigenesis.
1998,
Pubmed Peretz,
Tyrosine kinases modulate K+ channel gating in mouse Schwann cells.
1999,
Pubmed Ponniah,
Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.
1999,
Pubmed Prevarskaya,
Role of tyrosine phosphorylation in potassium channel activation. Functional association with prolactin receptor and JAK2 tyrosine kinase.
1995,
Pubmed Schaapveld,
Receptor-like protein tyrosine phosphatases: alike and yet so different.
1997,
Pubmed Schmidt,
Protein-tyrosine phosphatase activity regulates osteoclast formation and function: inhibition by alendronate.
1996,
Pubmed Shinder,
Structural basis of neuron-to-neuron cross-excitation in dorsal root ganglia.
1994,
Pubmed Siegelbaum,
Channel regulation. Ion channel control by tyrosine phosphorylation.
1994,
Pubmed Sobko,
Constitutive activation of delayed-rectifier potassium channels by a src family tyrosine kinase in Schwann cells.
1998,
Pubmed Sobko,
Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation.
1998,
Pubmed Su,
Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts.
1999,
Pubmed Szabò,
Tyrosine phosphorylation-dependent suppression of a voltage-gated K+ channel in T lymphocytes upon Fas stimulation.
1996,
Pubmed Tanuma,
Distinct promoters control transmembrane and cytosolic protein tyrosine phosphatase epsilon expression during macrophage differentiation.
1999,
Pubmed Timpe,
Modulation of a voltage-activated potassium channel by peptide growth factor receptors.
1994,
Pubmed
,
Xenbase Toledano-Katchalski,
The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2.
1999,
Pubmed Tonks,
From form to function: signaling by protein tyrosine phosphatases.
1996,
Pubmed Tsai,
The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity.
1997,
Pubmed Tsai,
Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity.
1999,
Pubmed
,
Xenbase Tybulewicz,
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene.
1991,
Pubmed Wallace,
Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma.
1999,
Pubmed Wang,
Regulation of a human neuronal voltage-gated potassium channel (hKv1.1) by protein tyrosine phosphorylation and dephosphorylation.
1999,
Pubmed Wong,
Leukocyte common antigen-related phosphatase (LRP) gene structure: conservation of the genomic organization of transmembrane protein tyrosine phosphatases.
1993,
Pubmed Yu,
Role of the outward delayed rectifier K+ current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons.
1999,
Pubmed Zondag,
Receptor protein tyrosine phosphatases: involvement in cell-cell interaction and signaling.
1997,
Pubmed
