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XB-ART-10749
Brain Res Dev Brain Res 2000 Jun 30;1212:219-22. doi: 10.1016/s0165-3806(00)00040-7.
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Expression of neural properties in olfactory cytokeratin-positive basal cell line.

Satoh M , Yoshida T .


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A cytokeratin (CK)(+), horizontal basal cell (HBC)-like cell line from murine olfactory epithelium, DBC1.2, was characterized. Histochemically, it is CK14(+), CK18(-), neuron-specific tubulin (NST)(+) and capable of binding Bandeiraea simplicifolia lectin I. RT-PCR studies revealed that it expresses mRNAs for EGF receptor, NST, Pax-6, but not for Mash-1 and neurogenin-1. Retinoic acid reduced the expression of CK14 and CKs recognized by polyclonal anti-keratin antibody, whereas it induced nestin. These results suggest that DBC1.2 shares the properties of HBCs and neural cells.

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Species referenced: Xenopus
Genes referenced: egf krt12.1 krt12.4 nes neurog1 tubb2b