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J Mol Neurosci
1999 Feb 01;121:11-22. doi: 10.1385/JMN:12:1:11.
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Characterization of the chicken transitin gene reveals a strong relationship to the nestin intermediate filament class.
Napier A
,
Yuan A
,
Cole GJ
.
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Our laboratory previously reported that transitin is a radial glial intermediate filament protein sharing the basic structural features common to all intermediate filament (IF) proteins. It contains an alpha-helical core domain flanked by a short nonhelical head and a long COOH-terminal tail. The core sequence of transitin shows the greatest similarity to Xenopus tanabin and to rat and human nestin. We also reported that transitin has multiple splice variants derived from the deletion or inclusion of a leucine-zipper heptad repeat domain in the COOH-terminal tail. In the present study, we provide new evidence to support the classification of nestin and transitin in the same group of IF proteins based on the number and position of its introns. In addition, we suggest that the different isoforms of transitin are produced by a splicing mechanism that recognizes consensus 5' and 3' splice sites contained within the coding sequence of the leucine-zipper heptad repeat domain.
Balcarek,
Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family.
1985, Pubmed
Balcarek,
Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family.
1985,
Pubmed
Balvay,
Pre-mRNA secondary structure and the regulation of splicing.
1993,
Pubmed
Chabot,
Transient expression of an intermediate filament-associated protein (IFAPa-400) during in vivo and in vitro differentiation of chick embryonic cells derived from neuroectoderm.
1990,
Pubmed
Cole,
Immunocytochemical localization of a novel radial glial intermediate filament protein.
1997,
Pubmed
Dahlstrand,
Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments.
1992,
Pubmed
Fuchs,
The cytoskeleton and disease: genetic disorders of intermediate filaments.
1996,
Pubmed
Fuchs,
Intermediate filaments: structure, dynamics, function, and disease.
1994,
Pubmed
Gounari,
Bovine filensin possesses primary and secondary structure similarity to intermediate filament proteins.
1993,
Pubmed
Hemken,
Molecular characteristics of the novel intermediate filament protein paranemin. Sequence reveals EAP-300 and IFAPa-400 are highly homologous to paranemin.
1997,
Pubmed
Hemmati-Brivanlou,
A protein expressed in the growth cones of embryonic vertebrate neurons defines a new class of intermediate filament protein.
1992,
Pubmed
,
Xenbase
Ho,
Intermediate filaments in the nervous system: implications in cancer.
1996,
Pubmed
Josephson,
POU transcription factors control expression of CNS stem cell-specific genes.
1998,
Pubmed
Kachinsky,
Intermediate filaments in cardiac myogenesis: nestin in the developing mouse heart.
1995,
Pubmed
Kelly,
Molecular characterization of EAP-300: a high molecular weight, embryonic polypeptide containing an amino acid repeat comprised of multiple leucine-zipper motifs.
1995,
Pubmed
Klymkowsky,
Intermediate filaments: new proteins, some answers, more questions.
1995,
Pubmed
Klymkowsky,
Intermediate filaments as dynamic structures.
1996,
Pubmed
Lee,
Neuronal intermediate filaments.
1996,
Pubmed
Lees,
The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it.
1988,
Pubmed
Lenardo,
Purified bovine NF-kappa B recognizes regulatory sequences in multiple genes expressed during activation of T- and B-lymphocytes.
1989,
Pubmed
Lendahl,
CNS stem cells express a new class of intermediate filament protein.
1990,
Pubmed
Lewis,
Anomalous placement of introns in a member of the intermediate filament multigene family: an evolutionary conundrum.
1986,
Pubmed
Li,
Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development.
1989,
Pubmed
Liou,
Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system.
1993,
Pubmed
Lothian,
An evolutionarily conserved region in the second intron of the human nestin gene directs gene expression to CNS progenitor cells and to early neural crest cells.
1997,
Pubmed
Mak,
KRC transcripts: identification of an unusual alternative splicing event.
1998,
Pubmed
Marchuk,
Remarkable conservation of structure among intermediate filament genes.
1984,
Pubmed
McCabe,
Distribution of the novel developmentally-regulated protein EAP-300 in the embryonic chick nervous system.
1992,
Pubmed
McCabe,
Expression of the barrier-associated proteins EAP-300 and claustrin in the developing central nervous system.
1992,
Pubmed
McCabe,
Developmentally regulated neural protein EAP-300 is expressed by myocardium and cardiac neural crest during chick embryogenesis.
1995,
Pubmed
Merdes,
The 47-kD lens-specific protein phakinin is a tailless intermediate filament protein and an assembly partner of filensin.
1993,
Pubmed
Myers,
The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family.
1987,
Pubmed
O'Hare,
Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression.
1988,
Pubmed
Sawada,
The predicted structure of chick lens CP49 and a variant thereof, CP49ins, the first vertebrate cytoplasmic intermediate filament protein with a lamin-like insertion in helix 1B.
1995,
Pubmed
Shapiro,
RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.
1987,
Pubmed
Steinert,
Molecular and cellular biology of intermediate filaments.
1988,
Pubmed
Takano,
Developmental change of the nestin-immunoreactive midline raphe glial structure in human brainstem and spinal cord.
1997,
Pubmed
Wegner,
POU-domain proteins: structure and function of developmental regulators.
1993,
Pubmed
Wirth,
An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity.
,
Pubmed
Yuan,
Molecular cloning of a new intermediate filament protein expressed by radial glia and demonstration of alternative splicing in a novel heptad repeat region located in the carboxy-terminal tail domain.
1997,
Pubmed
Zimmerman,
Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors.
1994,
Pubmed
