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XB-ART-11990
J Biol Chem 1999 Nov 19;27447:33198-201.
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A feedback loop coupling 5 S rRNA synthesis to accumulation of a ribosomal protein.

Pittman RH , Andrews MT , Setzer DR .


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We have shown that elevated expression of ribosomal protein L5 in Xenopus embryos results in the ectopic activation of 5 S rRNA genes that are normally inactive. This transcriptional stimulation mimics the effect of overexpressing transcription factor IIIA (TFIIIA), the 5 S rRNA gene-specific transcription factor. The results support a model in which a network of nucleic acid-protein interactions involving 5 S rRNA, the 5 S rRNA gene, TFIIIA, and L5 mediates both feedback inhibition of 5 S rRNA synthesis and coupling of 5 S rRNA synthesis to accumulation of a ribosomal protein, L5. We propose that these mechanisms contribute to the homeostatic control of ribosome assembly.

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Species referenced: Xenopus
Genes referenced: gtf3a