DNA Seq 1998 Jan 01;92:113-20. doi: 10.3109/10425179809086435.

Cloning of a cDNA for xDOR2, a novel TR2-related nuclear orphan receptor, expressed during neurulation in Xenopus laevis embryos.

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We isolated from neurulating Xenopus laevis (X. laevis) embryos a cDNA encoding a novel nuclear orphan receptor, Developmental Orphan Receptor 2 (xDOR2), closely related to Ambystoma mexicanum DORI (aDOR1) and to Testicular Receptor-2 (TR2) orphan receptor family members. The xDOR2 cDNA sequence which is truncated both at its 5' and 3' ends predicts a protein sequence of 542 amino acids. While the DNA-binding domain of xDOR2 shares 91%, and 92%, identity with those of aDOR1 and the TR2s, respectively, considerable divergence is observed at both extremities of the peptides. At the N-terminus, xDOR2 is 66% identical to aDOR1 and 64% to the TR2s. At the C-terminus, xDOR2 which is longer by 126 amino acids compared to aDOR1, shares 62%, identity with aDOR1 and appears to contain a complete ligand-binding domain. The DOR receptors appear to form a subtype distinct from the TR2s, and may play a role in the development and differentiation of neural tissues.

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Species referenced: Xenopus laevis
Genes referenced: depdc7 nr2c1