Pigment Cell Res 1999 Apr 01;122:98-106. doi: 10.1111/j.1600-0749.1999.tb00749.x.

Microtubule-organizing centers in the mitotic melanophores of Xenopus laevis larvae in vivo: ultrastructural study.

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Mitotic melanophores of Xenopus laevis larvae at 51-53 stages of development were morphologically studied using light and electron microscopy, with special reference to their microtubule-organizing centers. These melanophores represented a highly branched cell shape in mitosis, each cell process is distributed with melanosomes without exhibiting any responsiveness to hormonal (melatonin) stimulation, and upon completion of mitosis, recovered the ability to translocate these granules in response to such a stimulus. At the metaphase, these cells contained bipolar or multipolar spindles, whose poles were composed of three zones: the centrosome with centrioles; the centrosphere; and an outlying radial arrangement of microtubules and their associated inclusions. In these mitotic melanophores, a number of microtubules are distributed within the radially stretching cell processes, whereas an abundance of microtubules reside in the spindles. Possible origins of the microtubules observed in these cytoplasmic processes are discussed in relation to the loss of the ability of pigment translocation during mitosis.

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