Exp Nephrol 1998 Jan 01;65:421-8. doi: 10.1159/000020551.

Ultramicroanalysis of peptide profiles in biological samples using MALDI mass spectrometry.

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In the past few years, matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has emerged as a powerful tool for the direct analysis of peptide profiles contained in single neuroendocrine cells, tissue biopsies, as well as in releasates (after a simple sample clean-up). These studies were performed in both invertebrate (the pond snail) and vertebrate (xenopus and rat) species. The present article provides an overview of these data with a special emphasis on the sample handling required for each application.

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