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XB-ART-15625
Gene 1997 Dec 12;2032:235-40. doi: 10.1016/s0378-1119(97)00498-8.
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mRNA encoding the catalytic subunit of DNA-dependent protein kinase is widely expressed in Xenopus cells.

Labhart P .


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Here, the sequence of a Xenopus laevis cDNA encoding the 640 carboxy-terminal amino acids of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is reported. The predicted Xenopus protein segment is 65% identical to the human counterpart. Northern blot analysis indicates that Xenopus DNA-PKcs is encoded by an approx. 13000 nt transcript. DNA-PKcs mRNA is widely expressed in adult tissues as well as in oocytes and embryos. It is also shown that outside the conserved kinase domain, Xenopus DNA-PKcs bears significant similarities to hypothetical 420.8 and 433.2 kDa proteins in yeast species.

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