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XB-ART-15977
Biomed Environ Sci 1997 Sep 01;102-3:116-24.
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Selenocysteine tRNAs as central components of selenoprotein biosynthesis in eukaryotes.

Park SI , Park JM , Chittum HS , Yang ES , Carlson BA , Lee BJ , Hatfield DL .


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Selenocysteine (Sec) tRNAs serve as carrier molecules for the biosynthesis of Sec from serine and to donate Sec to protein in response to specific UGA codons. In this study, we describe the current status of Sec tRNAs in higher animals and further we examine: (i) the Sec tRNA population in Drosophila; (ii) transcription of the Sec tRNA in vivo (in Xenopus oocytes) and in vitro (in Xenopus oocyte extracts); (iii) the effect of selenium on the Sec tRNA population in various rat tissues following replenishment of extremely selenium deficient rats with this element; and (iv) the biosynthesis of the modified bases on Sec tRNA in Xenopus oocytes.

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Genes referenced: mt-tr trna