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Members of the transforming growth factor beta (TGF-beta) superfamily are involved in diverse physiological activities including development, tissue repair, hormone regulation, bone formation, cell growth, and differentiation. At the cellular level, these functions are initiated by the interaction of ligands with specific transmembrane receptors with intrinsic serine/threonine kinase activity. The signaling pathway that links receptor activation to the transcriptional regulation of the target genes is largely unknown. Recent work in Drosophila and Xenopus signaling suggested that Mad (Mothers against dpp) functions downstream of the receptors of the TGF-beta family. Mammalian Mad1 has been reported to respond to bone morphogenetic protein (BMP), but not to TGF-beta or activin. We report here the cloning and functional studies of a novel mammalian Mad molecule, Mad3, as well as a rat Mad1 homologue. Overexpression of Mad3 in a variety of cells stimulated basal transcriptional activity of the TGF-beta/activin-responsive reporter construct, p3TP-Lux. Furthermore, expression of Mad3 could potentiate the TGF-beta- and activin-induced transcriptional stimulation of p3TP-Lux. By contrast, overexpression of Mad1 inhibited the basal as well as the TGF-beta/activin induced p3TP-Lux activity. These findings, therefore, support the hypothesis that Mad3 may serve as a mediator linking TGF-beta/activin receptors to transcriptional regulation.
Angel,
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1.
1988, Pubmed
Angel,
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1.
1988,
Pubmed
Arora,
The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family.
1995,
Pubmed
Attisano,
Activation of signalling by the activin receptor complex.
1996,
Pubmed
Baker,
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.
1996,
Pubmed
,
Xenbase
Bassing,
A transforming growth factor beta type I receptor that signals to activate gene expression.
1994,
Pubmed
Cárcamo,
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.
1994,
Pubmed
Chang,
Requirements for transforming growth factor-beta regulation of the pro-alpha 2(I) collagen and plasminogen activator inhibitor-1 promoters.
1995,
Pubmed
Chen,
A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor.
1995,
Pubmed
Chen,
Cells arrested in G1 by the v-Abl tyrosine kinase do not express cyclin A despite the hyperphosphorylation of RB.
1996,
Pubmed
Chung,
An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta.
1996,
Pubmed
Ferguson,
Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo.
1992,
Pubmed
Gaddy-Kurten,
Activins and the receptor serine kinase superfamily.
1995,
Pubmed
Graff,
Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.
1996,
Pubmed
,
Xenbase
Grieder,
Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.
1995,
Pubmed
Hahn,
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.
1996,
Pubmed
Hawley,
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.
1995,
Pubmed
,
Xenbase
Hoodless,
MADR1, a MAD-related protein that functions in BMP2 signaling pathways.
1996,
Pubmed
Kawabata,
Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha.
1995,
Pubmed
Keeton,
Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.
1991,
Pubmed
Liu,
A human Mad protein acting as a BMP-regulated transcriptional activator.
1996,
Pubmed
,
Xenbase
Massagué,
The TGF-beta family and its composite receptors.
1994,
Pubmed
Mathews,
Expression cloning of an activin receptor, a predicted transmembrane serine kinase.
1991,
Pubmed
Padgett,
A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family.
,
Pubmed
Raftery,
Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.
1995,
Pubmed
Renshaw,
The human leukemia oncogene bcr-abl abrogates the anchorage requirement but not the growth factor requirement for proliferation.
1995,
Pubmed
Riggins,
Mad-related genes in the human.
1996,
Pubmed
Savage,
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.
1996,
Pubmed
Sekelsky,
Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.
1995,
Pubmed
Shibuya,
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.
1996,
Pubmed
Smith,
Mesoderm-inducing factors and mesodermal patterning.
1995,
Pubmed
,
Xenbase
Snutch,
Rat brain expresses a heterogeneous family of calcium channels.
1990,
Pubmed
,
Xenbase
Staehling-Hampton,
A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling.
1995,
Pubmed
Takeshita,
TGF-beta induces expression of monocyte chemoattractant JE/monocyte chemoattractant protein 1 via transcriptional factor AP-1 induced by protein kinase in osteoblastic cells.
1995,
Pubmed
Wang,
The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors.
1996,
Pubmed
Wang,
Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12.
1994,
Pubmed
Wang,
The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling.
1996,
Pubmed
Wieser,
Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region.
1993,
Pubmed
Wilson,
Induction of epidermis and inhibition of neural fate by Bmp-4.
1995,
Pubmed
,
Xenbase
Wrana,
Mechanism of activation of the TGF-beta receptor.
1994,
Pubmed
Wrana,
TGF beta signals through a heteromeric protein kinase receptor complex.
1992,
Pubmed
Yamaguchi,
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.
1995,
Pubmed
Zhang,
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
1996,
Pubmed
