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Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.
Fridell RA
,
Fischer U
,
Lührmann R
,
Meyer BE
,
Meinkoth JL
,
Malim MH
,
Cullen BR
.
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The human immunodeficiency virus type 1 (HIV-1) Rev protein is required for nuclear export of late HIV-1 mRNAs. This function is dependent on the mutationally defined Rev activation domain, which also forms a potent nuclear export signal. Transcription factor IIIA (TFIIIA) binds to 5S rRNA transcripts and this interaction has been proposed to play a role in the efficient nuclear export of 5S rRNA in amphibian oocytes. Here it is reported that amphibian TFIIIA proteins contain a sequence element with homology to the Rev activation domain that effectively substitutes for this domain in inducing the nuclear export of late HIV-1 mRNAs. It is further demonstrated that this TFIIIA sequence element functions as a protein nuclear export signal in both human cells and frog oocytes. Thus, this shared protein motif may play an analogous role in mediating the nuclear export of both late HIV-1 RNAs and 5S rRNA transcripts.
Bogerd,
Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.
1995, Pubmed
Bogerd,
Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.
1995,
Pubmed
Cullen,
Regulation of HIV gene expression.
1995,
Pubmed
Daly,
Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro.
1989,
Pubmed
Emerman,
The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization.
1989,
Pubmed
Engelke,
Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes.
1980,
Pubmed
,
Xenbase
Feinberg,
HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA.
1986,
Pubmed
Felber,
rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA.
1989,
Pubmed
Fischer,
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs.
1995,
Pubmed
Fischer,
Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA.
1994,
Pubmed
,
Xenbase
Fritz,
A human nucleoporin-like protein that specifically interacts with HIV Rev.
1995,
Pubmed
Gaskins,
Comparison of the sequence and structure of transcription factor IIIA from Bufo americanus and Rana pipiens.
1992,
Pubmed
,
Xenbase
Ginsberg,
Xenopus 5S gene transcription factor, TFIIIA: characterization of a cDNA clone and measurement of RNA levels throughout development.
1984,
Pubmed
,
Xenbase
Hammarskjöld,
Regulation of human immunodeficiency virus env expression by the rev gene product.
1989,
Pubmed
Heaphy,
Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich "bubble" located within the rev-responsive region of viral mRNAs.
1991,
Pubmed
Hope,
Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif.
1991,
Pubmed
Hope,
Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif.
1990,
Pubmed
Izaurralde,
RNA export.
1995,
Pubmed
Malim,
Mutational definition of the human immunodeficiency virus type 1 Rev activation domain.
1991,
Pubmed
Malim,
Functional dissection of the HIV-1 Rev trans-activator--derivation of a trans-dominant repressor of Rev function.
1989,
Pubmed
Malim,
HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence.
1990,
Pubmed
Malim,
HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latency.
1991,
Pubmed
Malim,
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA.
1989,
Pubmed
Malim,
Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes.
1993,
Pubmed
Meyer,
Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals.
1996,
Pubmed
Pelham,
A specific transcription factor that can bind either the 5S RNA gene or 5S RNA.
1980,
Pubmed
,
Xenbase
Picard,
Isolation of a 7S particle from Xenopus laevis oocytes: a 5S RNA-protein complex.
1979,
Pubmed
,
Xenbase
Sodroski,
A second post-transcriptional trans-activator gene required for HTLV-III replication.
,
Pubmed
Stutz,
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast.
1995,
Pubmed
Tiley,
Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteins.
1991,
Pubmed
Weichselbraun,
Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange.
1992,
Pubmed
Wen,
Identification of a signal for rapid export of proteins from the nucleus.
1995,
Pubmed
Zapp,
Sequence-specific RNA binding by the HIV-1 Rev protein.
1989,
Pubmed
