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Heteromeric connexons in lens gap junction channels.
Jiang JX
,
Goodenough DA
.
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Gap junction channels are formed by paired oligomeric membrane hemichannels called connexons, which are composed of proteins of the connexin family. Experiments with transfected cell lines and paired Xenopus oocytes have demonstrated that heterotypic intercellular channels which are formed by two connexons, each composed of a different connexin, can selectively occur. Studies by Stauffer [Stauffer, K. A. (1995) J. Biol. Chem. 270, 6768-6772] have shown that recombinant Cx26 and Cx32 coinfected into insect cells may form heteromeric connexons. By solubilizing and subfractionating individual connexons from ovine lenses, we show by immunoprecipitation that connexons can contain two different connexins forming heteromeric assemblies in vivo.
Barrio,
Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage.
1991, Pubmed,
Xenbase
Barrio,
Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage.
1991,
Pubmed
,
Xenbase
Bennett,
Gap junctions: new tools, new answers, new questions.
1991,
Pubmed
Beyer,
Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues.
1989,
Pubmed
Beyer,
Connexin family of gap junction proteins.
1990,
Pubmed
Bologna,
Organization of cytokeratin bundles by desmosomes in rat mammary cells.
1986,
Pubmed
Bruzzone,
Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins.
1993,
Pubmed
,
Xenbase
Buehler,
Single channel behavior of recombinant beta 2 gap junction connexons reconstituted into planar lipid bilayers.
1995,
Pubmed
Chen,
Multiple-channel conductance states and voltage regulation of embryonic chick cardiac gap junctions.
1992,
Pubmed
Clusin,
Activation of a voltage-insensitive conductance by inward calcium current.
1975,
Pubmed
Dahl,
Expression of functional cell-cell channels from cloned rat liver gap junction complementary DNA.
1987,
Pubmed
,
Xenbase
Elfgang,
Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells.
1995,
Pubmed
Goodenough,
Lens gap junctions: a structural hypothesis for nonregulated low-resistance intercellular pathways.
1979,
Pubmed
Gruijters,
Immunolocalization of MP70 in lens fiber 16-17-nm intercellular junctions.
1987,
Pubmed
Haefliger,
Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.
1992,
Pubmed
Hennemann,
Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: molecular cloning of mouse connexin31 and -45 cDNAs.
1992,
Pubmed
Jiang,
Molecular cloning and functional characterization of chick lens fiber connexin 45.6.
1994,
Pubmed
,
Xenbase
Jiang,
Posttranslational phosphorylation of lens fiber connexin46: a slow occurrence.
1993,
Pubmed
Jiang,
Changes in connexin expression and distribution during chick lens development.
1995,
Pubmed
,
Xenbase
Kanter,
Multiple connexins colocalize in canine ventricular myocyte gap junctions.
1993,
Pubmed
Kistler,
Identification of a 70,000-D protein in lens membrane junctional domains.
1985,
Pubmed
Kistler,
Homologies between gap junction proteins in lens, heart and liver.
1988,
Pubmed
Kistler,
Reconstitution of native-type noncrystalline lens fiber gap junctions from isolated hemichannels.
1994,
Pubmed
Konig,
Purification of bovine lens cell-to-cell channels composed of connexin44 and connexin50.
1995,
Pubmed
Lo,
Actin filament bundles are associated with fiber gap junctions in the primate lens.
1994,
Pubmed
Meda,
Differential expression of gap junction connexins in endocrine and exocrine glands.
1993,
Pubmed
Moore,
Selective block of gap junction channel expression with connexin-specific antisense oligodeoxynucleotides.
1994,
Pubmed
Musil,
Expression of the gap junction protein connexin43 in embryonic chick lens: molecular cloning, ultrastructural localization, and post-translational phosphorylation.
1990,
Pubmed
Musil,
Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines.
1990,
Pubmed
Musil,
Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER.
1993,
Pubmed
,
Xenbase
Nicholson,
Two homologous protein components of hepatic gap junctions.
,
Pubmed
Paul,
Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes.
1991,
Pubmed
,
Xenbase
Rubin,
Molecular analysis of voltage dependence of heterotypic gap junctions formed by connexins 26 and 32.
1992,
Pubmed
,
Xenbase
Stauffer,
The gap junction proteins beta 1-connexin (connexin-32) and beta 2-connexin (connexin-26) can form heteromeric hemichannels.
1995,
Pubmed
Stauffer,
Isolation and purification of gap junction channels.
1991,
Pubmed
Steinberg,
Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells.
1994,
Pubmed
Swenson,
Formation of gap junctions by expression of connexins in Xenopus oocyte pairs.
1989,
Pubmed
,
Xenbase
Van Roy,
Tumour invasion: effects of cell adhesion and motility.
1992,
Pubmed
Werner,
Formation of hybrid cell-cell channels.
1989,
Pubmed
,
Xenbase
White,
Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins.
1994,
Pubmed
,
Xenbase
