Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Biochem J
1995 Jun 15;308 ( Pt 3):839-46. doi: 10.1042/bj3080839.
Show Gene links
Show Anatomy links
The embryonic RNA helicase gene (ERH): a new member of the DEAD box family of RNA helicases.
Sowden J
,
Putt W
,
Morrison K
,
Beddington R
,
Edwards Y
.
???displayArticle.abstract???
DEAD box proteins share several highly conserved motifs including the characteristic Asp-Glu-Ala-Asp (D-E-A-D in the amino acid single-letter code) motif and have established or putative ATP-dependent RNA helicase activity. These proteins are implicated in a range of cellular processes that involve regulation of RNA function, including translation initiation, RNA splicing and ribosome assembly. Here we describe the isolation and characterization of an embryonic RNA helicase gene, ERH, which maps to mouse chromosome 1 and encodes a new member of the DEAD box family of proteins. The predicted ERH protein shows high sequence similarity to the testes-specific mouse PL10 and to the maternally acting Xenopus An3 helicase proteins. The ERH expression profile is similar, to that of An3, which localizes to the animal hemisphere of oocytes and is abundantly expressed in the embryo. ERH is expressed in oocytes and is a ubiquitous mRNA in the 9 days-post-conception embryo, and at later stages of development shows a more restricted pattern of expression in brain and kidney. The similarities in sequence and in expression profile suggest that ERH is the murine equivalent of the Xenopus An3 gene, and we propose that ERH plays a role in translational activation of mRNA in the oocyte and early embryo.
Altschul,
Basic local alignment search tool.
1990, Pubmed
Altschul,
Basic local alignment search tool.
1990,
Pubmed
Burd,
Conserved structures and diversity of functions of RNA-binding proteins.
1994,
Pubmed
Chomczynski,
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.
1987,
Pubmed
Ford,
Nuclear protein with sequence homology to translation initiation factor eIF-4A.
1988,
Pubmed
Fuller-Pace,
DbpA: a DEAD box protein specifically activated by 23s rRNA.
1993,
Pubmed
Fuller-Pace,
RNA helicases: modulators of RNA structure.
1994,
Pubmed
Gee,
Mouse erythroid cells express multiple putative RNA helicase genes exhibiting high sequence conservation from yeast to mammals.
1994,
Pubmed
Gorbalenya,
Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes.
1989,
Pubmed
Gururajan,
The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase.
1991,
Pubmed
,
Xenbase
Herrmann,
Cloning of the T gene required in mesoderm formation in the mouse.
1990,
Pubmed
Hirling,
RNA helicase activity associated with the human p68 protein.
1989,
Pubmed
Iost,
mRNAs can be stabilized by DEAD-box proteins.
1994,
Pubmed
Jamieson,
A suppressor of yeast spp81/ded1 mutations encodes a very similar putative ATP-dependent RNA helicase.
1991,
Pubmed
Jamieson,
A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.
1991,
Pubmed
Kozak,
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.
1986,
Pubmed
Lasko,
The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A.
1988,
Pubmed
Leroy,
The protein encoded by a murine male germ cell-specific transcript is a putative ATP-dependent RNA helicase.
1989,
Pubmed
Liang,
Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities.
1994,
Pubmed
Linder,
Birth of the D-E-A-D box.
1989,
Pubmed
Lyons,
Carbonic anhydrase III, an early mesodermal marker, is expressed in embryonic mouse skeletal muscle and notochord.
1991,
Pubmed
McGrew,
Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element.
1989,
Pubmed
,
Xenbase
Nielsen,
The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed.
1988,
Pubmed
Nishi,
An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly.
1988,
Pubmed
Pause,
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.
1992,
Pubmed
Pause,
The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.
1993,
Pubmed
Proudfoot,
3' non-coding region sequences in eukaryotic messenger RNA.
1976,
Pubmed
Ray,
ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors.
1985,
Pubmed
Rebagliati,
Identification and cloning of localized maternal RNAs from Xenopus eggs.
1985,
Pubmed
,
Xenbase
Richter,
Translational control in development: a perspective.
1993,
Pubmed
,
Xenbase
Roussell,
glh-1, a germ-line putative RNA helicase from Caenorhabditis, has four zinc fingers.
1993,
Pubmed
Rozen,
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.
1990,
Pubmed
Sallés,
Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation.
1992,
Pubmed
,
Xenbase
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Schmid,
D-E-A-D protein family of putative RNA helicases.
1992,
Pubmed
Thach,
Cap recap: the involvement of eIF-4F in regulating gene expression.
1992,
Pubmed
Walker,
Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.
1982,
Pubmed
Weeks,
A maternal mRNA localized to the animal pole of Xenopus eggs encodes a subunit of mitochondrial ATPase.
1987,
Pubmed
,
Xenbase
Whitehouse,
Phosphoglucomutase 1: complete human and rabbit mRNA sequences and direct mapping of this highly polymorphic marker on human chromosome 1.
1992,
Pubmed
Wilkinson,
Expression pattern of the mouse T gene and its role in mesoderm formation.
1990,
Pubmed
,
Xenbase
