XB-ART-2057
J Neurosci
2005 Apr 06;2514:3712-23. doi: 10.1523/JNEUROSCI.5389-03.2005.
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Rapid upregulation of alpha7 nicotinic acetylcholine receptors by tyrosine dephosphorylation.
Cho CH
,
Song W
,
Leitzell K
,
Teo E
,
Meleth AD
,
Quick MW
,
Lester RA
.
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Alpha7 nicotinic acetylcholine receptors (nAChRs) modulate network activity in the CNS. Thus, functional regulation of alpha7 nAChRs could influence the flow of information through various brain nuclei. It is hypothesized here that these receptors are amenable to modulation by tyrosine phosphorylation. In both Xenopus oocytes and rat hippocampal interneurons, brief exposure to a broad-spectrum protein tyrosine kinase inhibitor, genistein, specifically and reversibly potentiated alpha7 nAChR-mediated responses, whereas a protein tyrosine phosphatase inhibitor, pervanadate, caused depression. Potentiation was associated with an increased expression of surface alpha7 subunits and was not accompanied by detectable changes in receptor open probability, implying that the increased function results from an increased number of alpha7 nAChRs. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor-mediated exocytosis was shown to be a plausible mechanism for the rapid delivery of additional alpha7 nAChRs to the plasma membrane. Direct phosphorylation/dephosphorylation of alpha7 subunits was unlikely because mutation of all three cytoplasmic tyrosine residues did not prevent the genistein-mediated facilitation. Overall, these data are consistent with the hypothesis that the number of functional cell surface alpha7 nAChRs is controlled indirectly via processes involving tyrosine phosphorylation.
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References [+] :
Akiyama,
Genistein, a specific inhibitor of tyrosine-specific protein kinases.
1987, Pubmed
Akiyama, Genistein, a specific inhibitor of tyrosine-specific protein kinases. 1987, Pubmed
Alkondon, Neuronal nicotinic acetylcholine receptor activation modulates gamma-aminobutyric acid release from CA1 neurons of rat hippocampal slices. 1997, Pubmed
Alkondon, Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. II. The rundown and inward rectification of agonist-elicited whole-cell currents and identification of receptor subunits by in situ hybridization. 1994, Pubmed
Alkondon, Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons. 1997, Pubmed
Amin, Homomeric rho 1 GABA channels: activation properties and domains. 1994, Pubmed , Xenbase
Balasubramanian, Characterization of phosphotyrosine containing proteins at the cholinergic synapse. 1999, Pubmed
Barish, A transient calcium-dependent chloride current in the immature Xenopus oocyte. 1983, Pubmed , Xenbase
Belardetti, Up- and down-modulation of single K+ channel function by distinct second messengers. 1988, Pubmed
Bradbury, Characterization of the internalization pathways for the cystic fibrosis transmembrane conductance regulator. 1999, Pubmed
Brodin, Sequential steps in clathrin-mediated synaptic vesicle endocytosis. 2000, Pubmed
Brusés, Membrane lipid rafts are necessary for the maintenance of the (alpha)7 nicotinic acetylcholine receptor in somatic spines of ciliary neurons. 2001, Pubmed
Castel, Regulation of GABAA receptor by protein tyrosine kinases in frog pituitary melanotrophs. 2000, Pubmed
Chen, Protein tyrosine kinase-mediated potentiation of currents from cloned NMDA receptors. 1996, Pubmed , Xenbase
Colquhoun, Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. 1998, Pubmed
Conroy, Potentiation of alpha7-containing nicotinic acetylcholine receptors by select albumins. 2003, Pubmed
Cutting, Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. 1991, Pubmed , Xenbase
Davis, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. 1998, Pubmed
Davis, Regulation of ion channels by protein tyrosine phosphorylation. 2001, Pubmed
De Koninck, Differential regulation of neuronal nicotinic ACh receptor subunit genes in cultured neonatal rat sympathetic neurons: specific induction of alpha 7 by membrane depolarization through a Ca2+/calmodulin-dependent kinase pathway. 1995, Pubmed
Dineley, Amino acid determinants of alpha 7 nicotinic acetylcholine receptor surface expression. 2000, Pubmed
Drisdel, The role of palmitoylation in functional expression of nicotinic alpha7 receptors. 2004, Pubmed
Du, Differential modulation of nicotinic acetylcholine receptor subtypes and synaptic transmission in chick sympathetic ganglia by PGE(2). 2001, Pubmed
Eiselé, Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. 1993, Pubmed , Xenbase
Fenster, Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine. 1999, Pubmed , Xenbase
Fenster, Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine. 1997, Pubmed , Xenbase
Frazier, Synaptic potentials mediated via alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons. 1998, Pubmed
Frazier, Acetylcholine activates an alpha-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells. 1998, Pubmed
Glushakov, Modulation of nicotinic acetylcholine receptor activity in submucous neurons by intracellular messengers. 1999, Pubmed
Halevi, Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression. 2003, Pubmed , Xenbase
Hanke, Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. 1996, Pubmed
Haselbeck, Tyrosine kinase inhibitors alter composition of nicotinic receptors on neurons. 1996, Pubmed
Henderson, Nerve growth factor increases nicotinic ACh receptor gene expression and current density in wild-type and protein kinase A-deficient PC12 cells. 1994, Pubmed
Herzig, Effects of serine/threonine protein phosphatases on ion channels in excitable membranes. 2000, Pubmed
Hopfield, Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation. 1988, Pubmed
Jones, Functional nicotinic ACh receptors on interneurones in the rat hippocampus. 1997, Pubmed
Kassner, Differences in the fate of neuronal acetylcholine receptor protein expressed in neurons and stably transfected cells. 1997, Pubmed
Kawai, Nicotinic acetylcholine receptors containing alpha 7 subunits on rat cortical neurons do not undergo long-lasting inactivation even when up-regulated by chronic nicotine exposure. 2001, Pubmed
Kawai, Nicotinic alpha 7 receptor clusters on hippocampal GABAergic neurons: regulation by synaptic activity and neurotrophins. 2002, Pubmed
Köhr, Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family. 1996, Pubmed
Krause, Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor. 1998, Pubmed , Xenbase
Liu, Actin filaments and the opposing actions of CaM kinase II and calcineurin in regulating alpha7-containing nicotinic receptors on chick ciliary ganglion neurons. 1999, Pubmed
Liu, Insulin potentiates N-methyl-D-aspartate receptor activity in Xenopus oocytes and rat hippocampus. 1995, Pubmed , Xenbase
Liu, Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus. 2001, Pubmed
Malinow, AMPA receptor trafficking and synaptic plasticity. 2002, Pubmed
Mansvelder, Cellular and synaptic mechanisms of nicotine addiction. 2002, Pubmed
Margiotta, Cyclic AMP regulates the proportion of functional acetylcholine receptors on chicken ciliary ganglion neurons. 1987, Pubmed
Marks, Effects of chronic nicotine infusion on tolerance development and nicotinic receptors. 1983, Pubmed
McNiven, The dynamin family of mechanoenzymes: pinching in new places. 2000, Pubmed
Mei, Tyrosine phosphorylation and synapse formation at the neuromuscular junction. 1995, Pubmed
Meyer, Recruitment of a nicotinic acetylcholine receptor mutant lacking cytoplasmic tyrosine residues in its beta subunit into agrin-induced aggregates. 1998, Pubmed
Molinari, Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands. 1998, Pubmed
Montecucco, Structure and function of tetanus and botulinum neurotoxins. 1995, Pubmed
Moss, Phosphorylation of the predicted major intracellular domains of the rat and chick neuronal nicotinic acetylcholine receptor alpha 7 subunit by cAMP-dependent protein kinase. 1996, Pubmed
Neely, Trapping of an open-channel blocker at the frog neuromuscular acetylcholine channel. 1986, Pubmed
Papke, The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes. 1998, Pubmed , Xenbase
Papke, An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype. 1996, Pubmed , Xenbase
Peng, Chronic nicotine treatment up-regulates alpha3 and alpha7 acetylcholine receptor subtypes expressed by the human neuroblastoma cell line SH-SY5Y. 1997, Pubmed
Pereira, Identification and functional characterization of a new agonist site on nicotinic acetylcholine receptors of cultured hippocampal neurons. 1993, Pubmed
Qian, Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. 1997, Pubmed
Qu, The synapse-associated protein rapsyn regulates tyrosine phosphorylation of proteins colocalized at nicotinic acetylcholine receptor clusters. 1996, Pubmed
Rakhilin, alpha-bungarotoxin receptors contain alpha7 subunits in two different disulfide-bonded conformations. 1999, Pubmed
Ridley, Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells. 2001, Pubmed
Schwartz, Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. 1983, Pubmed
Séguéla, Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. 1993, Pubmed , Xenbase
Sheng, Postsynaptic signaling and plasticity mechanisms. 2002, Pubmed
Sheng, Molecular organization of the postsynaptic specialization. 2001, Pubmed
Skeberdis, Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis. 2001, Pubmed , Xenbase
Sterling, Tetanus toxin abolishes exocytosis of ROMK1 induced by inhibition of protein tyrosine kinase. 2003, Pubmed
Sterling, Inhibition of protein-tyrosine phosphatase stimulates the dynamin-dependent endocytosis of ROMK1. 2002, Pubmed
Sudhof, The synaptic vesicle cycle. 2004, Pubmed
Sweileh, Multistep expression and assembly of neuronal nicotinic receptors is both host-cell- and receptor-subtype-dependent. 2000, Pubmed
Wallace, Agrin induces phosphorylation of the nicotinic acetylcholine receptor. 1991, Pubmed
Wang, Regulation of the neuronal nicotinic acetylcholine receptor by SRC family tyrosine kinases. 2004, Pubmed
Wang, Regulation of NMDA receptors by tyrosine kinases and phosphatases. 1994, Pubmed
White, Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. 1990, Pubmed , Xenbase
Yang, A cysteine-rich isoform of neuregulin controls the level of expression of neuronal nicotinic receptor channels during synaptogenesis. 1998, Pubmed
Zwart, Differential modulation of alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors expressed in Xenopus oocytes by flufenamic acid and niflumic acid. 1995, Pubmed , Xenbase