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XB-ART-20911
Eur J Pharmacol 1994 Aug 16;2683:451-4. doi: 10.1016/0922-4106(94)90073-6.
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Receptor-mediated modulation of rat KV1.2 in Xenopus oocytes.

Murakoshi H , Ishii K , Nunoki K , Taira N .


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To investigate mechanisms for the receptor-mediated inhibition of a rat cardiac K+ channel clone (KV1.2), we coexpressed KV1.2 with a subtype of endothelin receptors (ETA) in Xenopus oocytes. Effects of endothelin ETA receptor stimulation were mimicked by application of PMA (4-beta-phorbol 12-myristate 13-acetate; 0.1 microM) or intracellular injection of CaCl2 (estimated concentration of 1 microM). These effects diminished in the presence of staurosporine (1 microM) or EGTA (estimated concentration of 5 mM). These results suggest that both activation of protein kinase C and an increase in intracellular Ca2+ contribute to the suppression.

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Species referenced: Xenopus
Genes referenced: ednra kcna2