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Receptor-mediated nucleocytoplasmic transport of clock proteins is an important, conserved element of the core mechanism for circadian rhythmicity. A systematic analysis of the nuclear export characteristics for the different murine period (mPER) and cryptochrome (mCRY) proteins using Xenopus oocytes as an experimental system demonstrates that all three mPER proteins, but neither mCRY1 nor mCRY2, are exported if injected individually. However, nuclear injection of heterodimeric complexes that contain combinations of mPER and mCRY proteins shows that mPER1 serves as an export adaptor for mCRY1 and mCRY2. Functional analysis of dominant-negative mPER1 variants designed either to sequester mPER3 to the cytoplasm or to inhibit nuclear export of mCRY1/2 in synchronized, stably transfected fibroblasts suggests that mPER1-mediated export of mCRY1/2 defines an important new element of the core clock machinery in vertebrates.
Akashi,
Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock.
2000, Pubmed
Akashi,
Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock.
2000,
Pubmed
Albrecht,
A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.
1997,
Pubmed
Albrecht,
The mammalian circadian clock.
2003,
Pubmed
Allada,
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless.
1998,
Pubmed
Allada,
Stopping time: the genetics of fly and mouse circadian clocks.
2001,
Pubmed
Bae,
Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock.
2001,
Pubmed
Balsalobre,
A serum shock induces circadian gene expression in mammalian tissue culture cells.
1998,
Pubmed
Bunger,
Mop3 is an essential component of the master circadian pacemaker in mammals.
2000,
Pubmed
Claussen,
Functional modules in ribosomal protein L5 for ribonucleoprotein complex formation and nucleocytoplasmic transport.
1999,
Pubmed
,
Xenbase
Darlington,
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.
1998,
Pubmed
Gekakis,
Role of the CLOCK protein in the mammalian circadian mechanism.
1998,
Pubmed
Izaurralde,
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus.
1997,
Pubmed
Kume,
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.
1999,
Pubmed
Lee,
Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock.
2004,
Pubmed
Lee,
The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex.
1998,
Pubmed
Lee,
PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription.
1999,
Pubmed
Miyazaki,
Nuclear entry mechanism of rat PER2 (rPER2): role of rPER2 in nuclear localization of CRY protein.
2001,
Pubmed
Motzkus,
The human PER1 gene is transcriptionally regulated by multiple signaling pathways.
2000,
Pubmed
Reppert,
Coordination of circadian timing in mammals.
2002,
Pubmed
Rupp,
Xenopus embryos regulate the nuclear localization of XMyoD.
1994,
Pubmed
,
Xenbase
Rutila,
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless.
1998,
Pubmed
Shearman,
Interacting molecular loops in the mammalian circadian clock.
2000,
Pubmed
Shearman,
Targeted disruption of the mPer3 gene: subtle effects on circadian clock function.
2000,
Pubmed
Shearman,
Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.
1997,
Pubmed
Sun,
RIGUI, a putative mammalian ortholog of the Drosophila period gene.
1997,
Pubmed
Tei,
Circadian oscillation of a mammalian homologue of the Drosophila period gene.
1997,
Pubmed
van der Horst,
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.
1999,
Pubmed
Vielhaber,
Nuclear export of mammalian PERIOD proteins.
2001,
Pubmed
,
Xenbase
Yagita,
Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.
2002,
Pubmed
Yagita,
Molecular mechanisms of the biological clock in cultured fibroblasts.
2001,
Pubmed
Yagita,
Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat-1 fibroblasts.
2000,
Pubmed
Zylka,
Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain.
1998,
Pubmed
