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XB-ART-22578
Biochim Biophys Acta 1993 May 28;11732:239-42.
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Cloning and sequencing of a Xenopus homologue of the inducible orphan receptor NGFI-B.

Smith TS , Matharu PJ , Sweeney GE .


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A cDNA clone encoding the NGFI-B transcription factor, a growth factor inducible member of the steroid/thyroid receptor superfamily, has been isolated from a Xenopus neurula (stage 17 embryo) library. Sequencing of this clone reveals an open reading frame encoding a 577 amino acid protein. Comparisons with its counterparts in rat, mouse and human show that the Xenopus protein has a well conserved DNA binding domain whereas homology in the carboxy terminal region, which includes the putative ligand binding domain, is lower than that typically observed in members of the steroid/thyroid receptor superfamily. This relative lack of homology suggests that, in Xenopus, the as-yet uncharacterized ligand may have subtle distinctions from its mammalian counterparts.

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Species referenced: Xenopus
Genes referenced: nr4a1 nr4a2