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Pleiotrophic effects of point mutations in yeast tRNA(Asp) on the base modification pattern.
Edqvist J
,
Stråby KB
,
Grosjean H
.
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The base-modification pattern has been studied in several synthetic variants of yeast tRNA(Asp) injected into Xenopus laevis oocytes. Certain point mutations in the D-stem and the variable loop of the tRNA led to considerably decreased levels of m1G37, psi 40 and Q34/manQ34 in the anticodon stem or loop and an increased rate of synthesis for m5C49 in the T-stem. The formation of m2G6 in the aminoacyl-stem was not affected in any of the tRNA-variants. Thus, mutations in one part of the tRNA-molecule can have long-range effects on the interactions between another part of the tRNA and the tRNA modifying enzymes.
Björk,
Transfer RNA modification.
1987,
Pubmed
Carbon,
Site-directed in vitro replacement of nucleosides in the anticodon loop of tRNA: application to the study of structural requirements for queuine insertase activity.
1983,
Pubmed
,
Xenbase
Davis,
The methylation of transfer RNA in Escherichia coli.
1974,
Pubmed
Droogmans,
Enzymatic conversion of guanosine 3' adjacent to the anticodon of yeast tRNAPhe to N1-methylguanosine and the wye nucleoside: dependence on the anticodon sequence.
1987,
Pubmed
,
Xenbase
Droogmans,
Enzymatic 2'-O-methylation of the wobble nucleoside of eukaryotic tRNAPhe: specificity depends on structural elements outside the anticodon loop.
1986,
Pubmed
,
Xenbase
Edmonds,
Posttranscriptional modification of tRNA in thermophilic archaea (Archaebacteria).
1991,
Pubmed
Grosjean,
The in vivo stability, maturation and aminoacylation of anticodon-substituted Escherichia coli initiator methionine tRNAs.
1987,
Pubmed
,
Xenbase
Grosjean,
Guanosine modifications in runoff transcripts of synthetic transfer RNA-Phe genes microinjected into Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Gu,
The T-arm of tRNA is a substrate for tRNA (m5U54)-methyltransferase.
1991,
Pubmed
Haumont,
Enzymatic conversion of adenosine to inosine in the wobble position of yeast tRNAAsp: the dependence on the anticodon sequence.
1984,
Pubmed
,
Xenbase
Haumont,
Enzymatic formation of queuosine and of glycosyl queuosine in yeast tRNAs microinjected into Xenopus laevis oocytes. The effect of the anticodon loop sequence.
1987,
Pubmed
,
Xenbase
Holmes,
Structural requirements for tRNA methylation. Action of Escherichia coli tRNA(guanosine-1)methyltransferase on tRNA(1Leu) structural variants.
1992,
Pubmed
Hori,
Effects of modification of 4-thiouridine in E. coli tRNA(fMet) on its methyl acceptor activity by thermostable Gm-methylases.
1989,
Pubmed
Kraus,
N2-guanine specific transfer RNA methyltransferase II from rat liver.
1974,
Pubmed
Melton,
Order and intracellular location of the events involved in the maturation of a spliced tRNA.
1980,
Pubmed
,
Xenbase
Nishimura,
Structure, biosynthesis, and function of queuosine in transfer RNA.
1983,
Pubmed
Perret,
Effect of conformational features on the aminoacylation of tRNAs and consequences on the permutation of tRNA specificities.
1992,
Pubmed
Perret,
Relaxation of a transfer RNA specificity by removal of modified nucleotides.
1990,
Pubmed
Pütz,
Identity elements for specific aminoacylation of yeast tRNA(Asp) by cognate aspartyl-tRNA synthetase.
1991,
Pubmed
Romby,
Comparison of the tertiary structure of yeast tRNA(Asp) and tRNA(Phe) in solution. Chemical modification study of the bases.
1987,
Pubmed
Schulman,
Recognition of tRNAs by aminoacyl-tRNA synthetases.
1991,
Pubmed
Sindhuphak,
Site specificities of three transfer RNA methyltransferases from yeast.
1985,
Pubmed
Sprinzl,
Compilation of tRNA sequences and sequences of tRNA genes.
1991,
Pubmed
Szweykowska-Kulinska,
Sequence and structure requirements for the biosynthesis of pseudouridine (psi 35) in plant pre-tRNA(Tyr).
1992,
Pubmed
Westhof,
Crystallographic refinement of yeast aspartic acid transfer RNA.
1985,
Pubmed
Wildenauer,
Enzymatic methylations: III. Cadaverine-induced conformational changes of E. coli tRNA fMet as evidenced by the availability of a specific adenosine and a specific cytidine residue for methylation.
1974,
Pubmed
