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Regulation of nicotinic acetylcholine receptor function by adenine nucleotides.
Eterović VA
,
Li L
,
Palma A
,
McNamee MG
.
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1. Nicotinic acetylcholine receptors (nAChR)4 from BC3H1 cells (which express a skeletal muscle-type receptor) and from Torpedo californica electric organ were expressed in Xenopus laevis oocytes and studied with a voltage-clamp technique. 2. We found that bath application of ATP in the micromolar to millimolar range increased the ACh-elicited current in both muscle and electrocyte receptors. The effect of ATP increased with successive applications. This "use-dependent" increase in potentiation was Ca2+ dependent, while the potentiation itself was not. 3. Four other nucleotides were tested on muscle nAChR: ADP, AMP, adenosine, and GTP. Of these, only ADP was a potentiator, but its effect was not use dependent. Neither ATP nor ADP affected the resting potential of the oocyte membrane. 4. ADP potentiated the response to suberyldicholine and nicotine, as well as ACh. 5. Finally, ADP reversed the phencyclidine-induced block of ACh currents in oocytes expressing muscle nAChR.
Akasu,
Effect of adenosine triphosphate on the sensitivity of the nicotinic acetylcholine-receptor in the bullfrog sympathetic ganglion cell.
1985, Pubmed
Akasu,
Effect of adenosine triphosphate on the sensitivity of the nicotinic acetylcholine-receptor in the bullfrog sympathetic ganglion cell.
1985,
Pubmed
Akasu,
Increase of acetylcholine-receptor sensitivity by adenosine triphosphate: a novel action of ATP on ACh-sensitivity.
1981,
Pubmed
Aronstam,
Binding of [3H]perhydrohistrionicotoxin and [3H]phencyclidine to the nicotinic receptor-ion channel complex of Torpedo electroplax. Inhibition by histrionicotoxins and derivatives.
1985,
Pubmed
Ehrlich,
Modulation of neuronal signal transduction systems by extracellular ATP.
1988,
Pubmed
Eterovic,
Positive modulators of muscle acetylcholine receptor.
1989,
Pubmed
Ewald,
Potentiation of postjunctional cholinergic sensitivity of rat diaphragm muscle by high-energy-phosphate adenine nucleotides.
1976,
Pubmed
Gordon,
Extracellular ATP: effects, sources and fate.
1986,
Pubmed
Huganir,
Protein phosphorylation of nicotinic acetylcholine receptors.
1989,
Pubmed
Lotan,
Adenosine-induced slow ionic currents in the Xenopus oocyte.
1982,
Pubmed
,
Xenbase
Lotan,
ATP-evoked membrane responses in Xenopus oocytes.
1986,
Pubmed
,
Xenbase
Miledi,
Effects of defolliculation on membrane current responses of Xenopus oocytes.
1989,
Pubmed
,
Xenbase
Mishina,
Location of functional regions of acetylcholine receptor alpha-subunit by site-directed mutagenesis.
,
Pubmed
,
Xenbase
Mosckovitz,
Localization of azidophencyclidine-binding site on the nicotinic acetylcholine receptor alpha-subunit.
1987,
Pubmed
Oswald,
Mechanism of phencyclidine binding to the acetylcholine receptor from Torpedo electroplaque.
1984,
Pubmed
Papke,
Mechanisms of noncompetitive inhibition of acetylcholine-induced single-channel currents.
1989,
Pubmed
Pradier,
Use of chemical modifications and site-directed mutagenesis to probe the functional role of thiol groups on the gamma subunit of Torpedo californica acetylcholine receptor.
1989,
Pubmed
,
Xenbase
Saji,
Depolarization and potentiation of responses to acetylcholine elicited by ATP on frog muscle.
1975,
Pubmed
