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XB-ART-26052
Am J Physiol 1990 Mar 01;2583 Pt 2:H903-6. doi: 10.1152/ajpheart.1990.258.3.H903.
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Human cardiac sodium channels expressed in Xenopus oocytes.

Tomaselli GF , Feldman AM , Yellen G , Marban E .


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We report the expression of voltage-dependent Na+ channels in Xenopus oocytes injected with total RNA isolated from explanted human hearts. The expressed channels demonstrate characteristic voltage-dependent gating, inhibition by tetrodotoxin, and selectivity for Na+. Oocytes injected with sterile water or intentionally degraded RNA had no similar channel activity. The antiarrhythmic agent lidocaine (20 microM) inhibits current flow through the channel in a voltage-dependent fashion. Na+ channels expressed by injection of human cardiac RNA into Xenopus oocytes qualitatively resemble channels in the native tissue.

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