Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
A detailed fate map of all the progeny derived from each of the blastomeres of the 4- and 8-cell stage South African clawed frog (Xenopus laevis) embryo is presented. Each "identified" blastomere that results from stereotypic cleavages has a characteristic set of progeny that distinguishes it from the other blastomeres of the embryo. The 4-cell dorsal (D) blastomere is the major progenitor of the stomodeum, cement gland, retina, notochord, headsomite, pharynx and liver. The 4-cell ventral (V) blastomere is the major progenitor of the trunk and finepidermis, ventralsomite, nephrotome, lateral plate mesoderm and proctodeum. The other organs are derived from both blastomeres. At the next cell division, the animal hemisphere daughters of both blastomeres (D1 and V1, respectively) become the major progenitors for head ectodermal and mesodermal structures, and the vegetal hemisphere daughters become the major progenitors for trunk mesodermal (D2) or trunk endodermal (V2) structures. Semiquantitative lineage diagrams, using data from this and from previous studies demonstrate that as cleavage proceeds from the 2- to the 32-cell stage, the progenitors for particular organs or for specific regions of organs segregate into defined regions of the blastula. To determine whether this segregation is related to the position of the blastomere or to its geneological lineage, we compared the fates of radial 8-cell blastomeres to those of stereotypic 8-cell blastomeres. Radial blastomeres have fates nearly equivalent to the sum of the two 16-cell blastomeres that occupy the same position in the embryo, demonstrating that fate depends upon blastomere position rather than lineage.
Heasman,
Fates and states of determination of single vegetal pole blastomeres of X. laevis.
1984, Pubmed,
Xenbase
Heasman,
Fates and states of determination of single vegetal pole blastomeres of X. laevis.
1984,
Pubmed
,
Xenbase
Hirose,
Clonal organization of the central nervous system of the frog. I. Clones stemming from individual blastomeres of the 16-cell and earlier stages.
1979,
Pubmed
,
Xenbase
Jacobson,
Clonal analysis and cell lineages of the vertebrate central nervous system.
1985,
Pubmed
,
Xenbase
Jacobson,
States of determination of single cells transplanted between 512-cell Xenopus embryos.
1989,
Pubmed
,
Xenbase
Jacobson,
Clonal organization of the central nervous system of the frog. II. Clones stemming from individual blastomeres of the 32- and 64-cell stages.
1981,
Pubmed
,
Xenbase
Kageura,
Pattern regulation in defect embryos of Xenopus laevis.
1984,
Pubmed
,
Xenbase
Kageura,
Pattern regulation in isolated halves and blastomeres of early Xenopus laevis.
1983,
Pubmed
,
Xenbase
Kimmel,
Cell lineage of zebrafish blastomeres. III. Clonal analyses of the blastula and gastrula stages.
1985,
Pubmed
Klein,
Lithium changes the ectodermal fate of individual frog blastomeres because it causes ectopic neural plate formation.
1989,
Pubmed
,
Xenbase
Klein,
The first cleavage furrow demarcates the dorsal-ventral axis in Xenopus embryos.
1987,
Pubmed
,
Xenbase
Moody,
Quantitative lineage analysis of the origin of frog primary motor and sensory neurons from cleavage stage blastomeres.
1989,
Pubmed
,
Xenbase
Moody,
Fates of the blastomeres of the 16-cell stage Xenopus embryo.
1987,
Pubmed
,
Xenbase
Moody,
Fates of the blastomeres of the 32-cell-stage Xenopus embryo.
1987,
Pubmed
,
Xenbase
Newport,
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.
1982,
Pubmed
,
Xenbase
Nishida,
Cell lineage analysis in ascidian embryos by intracellular injection of a tracer enzyme. I. Up to the eight-cell stage.
1983,
Pubmed
Stent,
Cell lineage in the development of invertebrate nervous systems.
1985,
Pubmed
Stent,
The role of cell lineage in development.
1985,
Pubmed
Sulston,
The embryonic cell lineage of the nematode Caenorhabditis elegans.
1983,
Pubmed
Weisblat,
Embryonic cell lineages in the nervous system of the glossiphoniid leech Helobdella triserialis.
1980,
Pubmed
Weisblat,
Embryonic origins of cells in the leech Helobdella triserialis.
1984,
Pubmed
Ziomek,
The developmental potential of mouse 16-cell blastomeres.
1982,
Pubmed
