XB-ART-27415
Eur J Pharmacol
1988 Jul 14;1513:497-500. doi: 10.1016/0014-2999(88)90551-1.
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The endogenous muscarinic acetylcholine receptor in Xenopus oocytes is of the M3 subtype.
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The muscarinic acetylcholine receptor of the Xenopus oocyte was characterized electrophysiologically. Iontophoretic responses to acetylcholine were inhibited by the muscarinic antagonists 4-DAMP, pirenzepine and AF-DX 116 at respective IC50 values of 7 nM, 15 microM and 2 microM. This antagonist sensitivity order indicates that the receptor is of the M3 muscarinic subtype.
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