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J Mol Evol
1987 Jan 01;244:297-308. doi: 10.1007/bf02134128.
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Nucleotide sequence of the delta-beta-globin intergenic segment in the macaque: structure and evolutionary rates in higher primates.
Savatier P
,
Trabuchet G
,
Chebloune Y
,
Faure C
,
Verdier G
,
Nigon VM
.
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A 5600-base-pair (bp) fragment including the beta-globin gene and about 4000 bp of its 5' flanking sequence was cloned from the DNA of Macaca cynomolgus (an Old World monkey), and the 5' flanking region was sequenced. Comparison with human, chimpanzee, mouse, rabbit, and Xenopus orthologous sequences reveals a tandemly repeated sequence called RS4 at the same position (about 500 bp 5' from the transcription start of the adult beta-globin gene) in all six species. We suggest that a tandemly repeated sequence has been maintained by functional constraints since the divergence between amphibians and reptiles. Excluding tandemly repeated sequences as well as about 400 nucleotides upstream from the cap site, the average base substitution frequencies among human, chimpanzee, and macaque intergenic sequences were calculated. They appear to be strongly correlated with the delta T50 values measured between the corresponding nuclear DNAs. They are also similar to base substitution frequencies calculated by Chang and Slightom (1984) at the pseudo-eta-globin locus. Thus, exclusion of sequences involved in specific modes of variation might allow the use of intergenic sequences for the accurate calculation of genetic distances. Using a time scale based on the dating of the Atlantic split, we estimate the base substitution rate of primate noncoding DNA to be 1.0 X 10(-9) substitution/site/year.
Antonarakis,
DNA polymorphism and molecular pathology of the human globin gene clusters.
1985, Pubmed
Antonarakis,
DNA polymorphism and molecular pathology of the human globin gene clusters.
1985,
Pubmed
Benveniste,
Evolution of type C viral genes: evidence for an Asian origin of man.
1976,
Pubmed
Benveniste,
Evolution of type C viral genes: preservation of ancestral murine type C viral sequences in pig cellular DNA.
1975,
Pubmed
Biggin,
Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.
1983,
Pubmed
Britten,
Rates of DNA sequence evolution differ between taxonomic groups.
1986,
Pubmed
Chang,
Isolation and nucleotide sequence analysis of the beta-type globin pseudogene from human, gorilla and chimpanzee.
1984,
Pubmed
Charnay,
Linker scanning mutagenesis of the 5'-flanking region of the mouse beta-major-globin gene: sequence requirements for transcription in erythroid and nonerythroid cells.
1985,
Pubmed
Chebloune,
A new method for detection of small modifications in genomic DNA, applied to the human delta-beta globin gene cluster.
1984,
Pubmed
Collins,
The molecular genetics of human hemoglobin.
1984,
Pubmed
Dierks,
Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells.
1983,
Pubmed
Dierks,
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus.
1981,
Pubmed
Easteal,
Generation time and the rate of molecular evolution.
1985,
Pubmed
Fordis,
The 5'-flanking sequences of human globin genes contribute to tissue specific expression.
1986,
Pubmed
Giebel,
Nucleotide sequence, evolution, and expression of the fetal globin gene of the spider monkey Ateles geoffroyi.
1985,
Pubmed
Gilmour,
A negative regulatory sequence near the mouse beta-maj globin gene associated with a region of potential Z-DNA.
1984,
Pubmed
Goodman,
The eta-globin gene. Its long evolutionary history in the beta-globin gene family of mammals.
1984,
Pubmed
Greaves,
(AT)n is an interspersed repeat in the Xenopus genome.
1985,
Pubmed
,
Xenbase
Grosveld,
Sequence requirements for the transcription of the rabbit beta-globin gene in vivo: the -80 region.
1982,
Pubmed
Hamada,
Enhanced gene expression by the poly(dT-dG).poly(dC-dA) sequence.
1984,
Pubmed
Hardies,
Evolution of the mammalian beta-globin gene cluster.
1984,
Pubmed
Hardison,
Rabbit globin pseudogene psi beta 2 is a hybrid of delta- and beta-globin gene sequences.
1984,
Pubmed
Harris,
The primate psi beta 1 gene. An ancient beta-globin pseudogene.
1984,
Pubmed
Hasson,
Simian virus 40 illegitimate recombination occurs near short direct repeats.
1984,
Pubmed
Helm-Bychowski,
Rates of nuclear DNA evolution in pheasant-like birds: evidence from restriction maps.
1986,
Pubmed
Hutchison,
The mouse globin pseudogene beta h3 is descended from a premammalian delta-globin gene.
1984,
Pubmed
Kimura,
Estimation of evolutionary distances between homologous nucleotide sequences.
1981,
Pubmed
Koop,
Primate eta-globin DNA sequences and man's place among the great apes.
,
Pubmed
Lanave,
Mammalian genes as molecular clocks?
,
Pubmed
Leder,
EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the lambdagtWES system.
1977,
Pubmed
Li,
A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes.
1985,
Pubmed
Maeda,
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene.
1983,
Pubmed
Messing,
A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.
1982,
Pubmed
Miesfeld,
A member of a new repeated sequence family which is conserved throughout eucaryotic evolution is found between the human delta and beta globin genes.
1981,
Pubmed
,
Xenbase
Miyata,
Molecular evolution of mRNA: a method for estimating evolutionary rates of synonymous and amino acid substitutions from homologous nucleotide sequences and its application.
1980,
Pubmed
Moschonas,
The DNA sequence of the 5' flanking region of the human beta-globin gene: evolutionary conservation and polymorphic differences.
1982,
Pubmed
Needleman,
A general method applicable to the search for similarities in the amino acid sequence of two proteins.
1970,
Pubmed
O'Brien,
A molecular solution to the riddle of the giant panda's phylogeny.
,
Pubmed
Orkin,
The mutation and polymorphism of the human beta-globin gene and its surrounding DNA.
1984,
Pubmed
Perler,
The evolution of genes: the chicken preproinsulin gene.
1980,
Pubmed
Poncz,
"Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method.
1982,
Pubmed
Poncz,
Nucleotide sequence analysis of the delta beta-globin gene region in humans.
1983,
Pubmed
Rich,
Right-handed and left-handed DNA: conformational information in genetic material.
1983,
Pubmed
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Savatier,
Nucleotide sequence of the beta-globin genes in gorilla and macaque: the origin of nucleotide polymorphisms in human.
1987,
Pubmed
Savatier,
Evolution of the primate beta-globin gene region. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee.
1985,
Pubmed
Sawada,
Intergenic DNA sequences flanking the pseudo alpha globin genes of human and chimpanzee.
1983,
Pubmed
Scott,
The sequence of the gorilla fetal globin genes: evidence for multiple gene conversions in human evolution.
1984,
Pubmed
Semenza,
Detection of a novel DNA polymorphism in the beta-globin gene cluster.
1984,
Pubmed
Semenza,
The silent carrier allele: beta thalassemia without a mutation in the beta-globin gene or its immediate flanking regions.
1984,
Pubmed
Sibley,
The phylogeny of the hominoid primates, as indicated by DNA-DNA hybridization.
1984,
Pubmed
Slightom,
Chimpanzee fetal G gamma and A gamma globin gene nucleotide sequences provide further evidence of gene conversions in hominine evolution.
1985,
Pubmed
Spritz,
Duplication/deletion polymorphism 5' - to the human beta globin gene.
1981,
Pubmed
Struhl,
Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast.
1985,
Pubmed
Townes,
Erythroid-specific expression of human beta-globin genes in transgenic mice.
1985,
Pubmed
White,
The diagonal-traverse homology search algorithm for locating similarities between two sequences.
1984,
Pubmed
Wright,
DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells.
1984,
Pubmed
Wu,
Evidence for higher rates of nucleotide substitution in rodents than in man.
1985,
Pubmed
