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XB-ART-32952
Proc Natl Acad Sci U S A 1974 Aug 01;718:3143-6.
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Role of the polyadenylate segment in the translation of globin messenger RNA in Xenopus oocytes.

Huez G , Marbaix G , Hubert E , Leclercq M , Nudel U , Soreq H , Salomon R , Lebleu B , Revel M , Littauer UZ .


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The translations of native messenger RNA for rabbit globin and that of poly(A)-free globin messenger RNA have been compared after injection into Xenopus oocytes. The initial rate of translation of poly(A)-free mRNA is close to that found with intact mRNA. However, at longer incubation periods, the rate of globin synthesis with poly(A)-free mRNA is considerably lower than with native mRNA. Similar differences in the template activity of the two mRNA preparations were found with a cell-free extract of Krebs II ascites tumor. It is concluded that the presence of the 3' poly(A)-rich sequence in mRNA is required to ensure high functional stability.

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References [+] :
Adesnik, Evidence that all messenger RNA molecules (except histone messenger RNA) contain Poly (A) sequences and that the Poly(A) has a nuclear function. 1972, Pubmed