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Biochem Biophys Res Commun
2006 Dec 15;3512:424-30. doi: 10.1016/j.bbrc.2006.10.054.
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Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid.
Liu Z
,
Sanchez MA
,
Jiang X
,
Boles E
,
Landfear SM
,
Rosen BP
.
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Arsenic exposure is associated with hypertension, diabetes, and cancer. Some mammals methylate arsenic. Saccharomyces cerevisiae hexose permeases catalyze As(OH)(3) uptake. Here, we report that mammalian glucose transporter GLUT1 catalyzes As(OH)(3) and CH(3)As(OH)(2) uptake in yeast or in Xenopus laevis oocytes. Expression of GLUT1 in a yeast lacking other glucose transporters allows for growth on glucose. Yeast expressing yeast HXT1 or rat GLUT1 transport As(OH)(3) and CH(3)As(OH)(2). The K(m) of GLUT1 is to 1.2mM for CH(3)As(OH)(2), compared to a K(m) of 3mM for glucose. Inhibition between glucose and CH(3)As(OH)(2) is noncompetitive, suggesting differences between the translocation pathways of hexoses and arsenicals. Both human and rat GLUT1 catalyze uptake of both As(OH)(3) and CH(3)As(OH)(2) in oocytes. Thus GLUT1 may be a major pathway uptake of both inorganic and methylated arsenicals in erythrocytes or the epithelial cells of the blood-brain barrier, contributing to arsenic-related cardiovascular problems and neurotoxicity.
Abel,
Glucose transport in the heart.
2004, Pubmed
Abel,
Glucose transport in the heart.
2004,
Pubmed
Abernathy,
Health effects and risk assessment of arsenic.
2003,
Pubmed
Arriza,
Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.
1993,
Pubmed
,
Xenbase
Dan-Goor,
Expression of glucose transporter and glucose uptake in human oocytes and preimplantation embryos.
1997,
Pubmed
Doege,
Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle.
2001,
Pubmed
Douer,
Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies.
2005,
Pubmed
Elkjaer,
Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain.
2000,
Pubmed
Erry,
The distribution of arsenic in the body tissues of wood mice and bank voles.
2005,
Pubmed
Fischbarg,
Glucose transporters serve as water channels.
1990,
Pubmed
,
Xenbase
Ghosh,
Pathways of As(III) detoxification in Saccharomyces cerevisiae.
1999,
Pubmed
Iserovich,
Changes in glucose transport and water permeability resulting from the T310I pathogenic mutation in Glut1 are consistent with two transport channels per monomer.
2002,
Pubmed
,
Xenbase
Ishibashi,
Cellular localization of aquaporin 7 in the rat kidney.
2000,
Pubmed
Ishibashi,
Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea.
1997,
Pubmed
,
Xenbase
Kageyama,
Expression of aquaporins 7 and 8 in the developing rat testis.
2001,
Pubmed
Kasahara,
Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae.
1996,
Pubmed
Klepper,
Facilitated glucose transporter protein type 1 (GLUT1) deficiency syndrome: impaired glucose transport into brain-- a review.
2002,
Pubmed
Langford,
Biochemistry and molecular genetics of Leishmania glucose transporters.
1994,
Pubmed
,
Xenbase
Lehmann,
Aquaporin water channels in central nervous system.
2004,
Pubmed
Liu,
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9.
2002,
Pubmed
,
Xenbase
Liu,
Arsenic trioxide uptake by human and rat aquaglyceroporins.
2004,
Pubmed
,
Xenbase
Liu,
Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae.
2004,
Pubmed
Liu,
Methylarsonous acid transport by aquaglyceroporins.
2006,
Pubmed
Mandal,
Speciation of arsenic in biological samples.
2004,
Pubmed
Mueckler,
Facilitative glucose transporters.
1994,
Pubmed
Navas-Acien,
Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidence.
2005,
Pubmed
Rahman,
Diabetes mellitus associated with arsenic exposure in Bangladesh.
1998,
Pubmed
Ramírez-Solís,
Experimental and theoretical characterization of arsenite in water: insights into the coordination environment of As-O.
2004,
Pubmed
Reifenberger,
Kinetic characterization of individual hexose transporters of Saccharomyces cerevisiae and their relation to the triggering mechanisms of glucose repression.
1997,
Pubmed
Suzuki-Toyota,
Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis.
1999,
Pubmed
Takata,
Transport of glucose across the blood-tissue barriers.
1997,
Pubmed
Tchounwou,
Carcinogenic and systemic health effects associated with arsenic exposure--a critical review.
2003,
Pubmed
Thomas,
Elucidating the pathway for arsenic methylation.
2004,
Pubmed
Tsukaguchi,
Functional and molecular characterization of the human neutral solute channel aquaporin-9.
1999,
Pubmed
,
Xenbase
Vannucci,
Glucose transporter proteins in brain: delivery of glucose to neurons and glia.
1997,
Pubmed
Wieczorke,
Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae.
1999,
Pubmed
Wieczorke,
Characterisation of mammalian GLUT glucose transporters in a heterologous yeast expression system.
2003,
Pubmed
Wildfang,
Enzymatic methylation of arsenic compounds. IX. Liver arsenite methyltransferase and arsenate reductase activities in primates.
2001,
Pubmed
Wysocki,
The Saccharomyces cerevisiae ACR3 gene encodes a putative membrane protein involved in arsenite transport.
1997,
Pubmed
Zierold,
Prevalence of chronic diseases in adults exposed to arsenic-contaminated drinking water.
2004,
Pubmed
