XB-ART-3485
J Physiol
2004 Jul 15;558Pt 2:659-69. doi: 10.1113/jphysiol.2004.066001.
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Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing.
Roza C
,
Puel JL
,
Kress M
,
Baron A
,
Diochot S
,
Lazdunski M
,
Waldmann R
.
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Mechanosensitive cation channels are thought to be crucial for different aspects of mechanoperception, such as hearing and touch sensation. In the nematode C. elegans, the degenerins MEC-4 and MEC-10 are involved in mechanosensation and were proposed to form mechanosensitive cation channels. Mammalian degenerin homologues, the H(+)-gated ASIC channels, are expressed in sensory neurones and are therefore interesting candidates for mammalian mechanosensors. We investigated the effect of an ASIC2 gene knockout in mice on hearing and on cutaneous mechanosensation and visceral mechanonociception. However, our data do not support a role of ASIC2 in those facets of mechanoperception.
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Species referenced: Xenopus laevis
Genes referenced: asic1 asic2
References [+] :
Akopian,
A new member of the acid-sensing ion channel family.
2000, Pubmed
Akopian, A new member of the acid-sensing ion channel family. 2000, Pubmed
Alessandri-Haber, Hypotonicity induces TRPV4-mediated nociception in rat. 2003, Pubmed
Babinski, Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. 1999, Pubmed , Xenbase
Babinski, Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. 2000, Pubmed , Xenbase
Baron, Zn2+ and H+ are coactivators of acid-sensing ion channels. 2001, Pubmed , Xenbase
Baron, ASIC-like, proton-activated currents in rat hippocampal neurons. 2002, Pubmed
Bernardini, Muscarinic M2 receptors on peripheral nerve endings: a molecular target of antinociception. 2002, Pubmed
Booth, Managing hypoosmotic stress: aquaporins and mechanosensitive channels in Escherichia coli. 1999, Pubmed
Burnstock, Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction. 1999, Pubmed
Caterina, The capsaicin receptor: a heat-activated ion channel in the pain pathway. 1997, Pubmed , Xenbase
Champigny, Mutations causing neurodegeneration in Caenorhabditis elegans drastically alter the pH sensitivity and inactivation of the mammalian H+-gated Na+ channel MDEG1. 1998, Pubmed , Xenbase
Chelur, The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. 2002, Pubmed , Xenbase
Cho, Mechanosensitive ion channels in cultured sensory neurons of neonatal rats. 2002, Pubmed
Cody, Acoustically induced hearing loss: intracellular studies in the guinea pig cochlea. 1988, Pubmed
Colbert, OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. 1997, Pubmed
Dallos, Neurobiology of cochlear inner and outer hair cells: intracellular recordings. 1986, Pubmed
Drew, Distinct mechanosensitive properties of capsaicin-sensitive and -insensitive sensory neurons. 2002, Pubmed
Drew, Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. 2004, Pubmed
Ernstrom, Genetics of sensory mechanotransduction. 2002, Pubmed
Escoubas, Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels. 2000, Pubmed , Xenbase
Ettaiche, Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration. 2004, Pubmed
Forster, Automatic classification and analysis of microneurographic spike data using a PC/AT. 1990, Pubmed
García-Añoveros, Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons. 2001, Pubmed
García-Añoveros, BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. 1997, Pubmed
Gillespie, Molecular basis of mechanosensory transduction. 2001, Pubmed
Goodman, MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. 2002, Pubmed , Xenbase
Grigg, Stretch sensitivity of cutaneous afferent neurons. 2002, Pubmed
Guitton, Salicylate induces tinnitus through activation of cochlear NMDA receptors. 2003, Pubmed
Hamill, Molecular basis of mechanotransduction in living cells. 2001, Pubmed , Xenbase
Hamill, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. 1981, Pubmed
Hedges, The origin and evolution of model organisms. 2002, Pubmed
Huang, Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans. 1994, Pubmed
Jospin, Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle. 2004, Pubmed
Jørgensen, Amiloride blocks the mechano-electrical transduction channel of hair cells of the chick. 1988, Pubmed
Kass, The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans. 2001, Pubmed
Kim, A TRPV family ion channel required for hearing in Drosophila. 2003, Pubmed
Koltzenburg, Receptive properties of mouse sensory neurons innervating hairy skin. 1997, Pubmed
Kress, Role of [Ca2+]i in the ATP-induced heat sensitization process of rat nociceptive neurons. 1999, Pubmed
Krishtal, The ASICs: signaling molecules? Modulators? 2003, Pubmed
Lingueglia, A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. 1997, Pubmed
Liu, Interaction between a putative mechanosensory membrane channel and a collagen. 1996, Pubmed
McCarter, Mechanical transduction by rat dorsal root ganglion neurons in vitro. 1999, Pubmed
McCleskey, Ion channels of nociception. 1999, Pubmed
McKemy, Identification of a cold receptor reveals a general role for TRP channels in thermosensation. 2002, Pubmed , Xenbase
Patel, Lipid and mechano-gated 2P domain K(+) channels. 2001, Pubmed
Patuzzi, Outer hair cell receptor current and sensorineural hearing loss. 1989, Pubmed
Price, The mammalian sodium channel BNC1 is required for normal touch sensation. 2000, Pubmed
Price, The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. 2001, Pubmed
Price, Cloning and expression of a novel human brain Na+ channel. 1996, Pubmed , Xenbase
Roza, Substance P, calcitonin gene related peptide and PGE2 co-released from the mouse colon: a new model to study nociceptive and inflammatory responses in viscera, in vitro. 2001, Pubmed
Sidi, NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. 2003, Pubmed
Strassmaier, The hair cell's transduction channel. 2002, Pubmed
Su, Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. 1998, Pubmed
Sutherland, Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. 2001, Pubmed
Suzuki, In vivo imaging of C. elegans mechanosensory neurons demonstrates a specific role for the MEC-4 channel in the process of gentle touch sensation. 2003, Pubmed
Tominaga, The cloned capsaicin receptor integrates multiple pain-producing stimuli. 1998, Pubmed , Xenbase
Waldmann, Functional degenerin-containing chimeras identify residues essential for amiloride-sensitive Na+ channel function. 1995, Pubmed
Waldmann, The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. 1996, Pubmed
Waldmann, A proton-gated cation channel involved in acid-sensing. 1997, Pubmed , Xenbase
Waldmann, Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons. 1997, Pubmed
Waldmann, H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels. 1998, Pubmed
Walker, A Drosophila mechanosensory transduction channel. 2000, Pubmed
de Weille, Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. 1998, Pubmed