Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-35397
FEBS Lett 2006 Oct 16;58024:5728-32. doi: 10.1016/j.febslet.2006.09.030.
Show Gene links Show Anatomy links

Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels.

Cuypers E , Yanagihara A , Karlsson E , Tytgat J .


???displayArticle.abstract???
Cnidarian envenomations cause a burning-pain sensation of which the underlying mechanisms are unknown. Activation of TRPV1, a non-selective cation channel expressed in nociceptive neurons, leads to cell depolarisation and pain. Here, we show in vitro and in vivo evidence for desensitization-dependent TRPV1 activation in cnidarian envenomations. Cnidarian venom induced a nociceptive reactivity, comparable to capsaicin, in laboratory rats, which could be reduced by the selective TRPV1 antagonist, BCTC. These findings are the first to explain at least part of the symptomology of cnidarian envenomations and provide insights into the design of more effective treatments for this global public health problem.

???displayArticle.pubmedLink??? 17010344
???displayArticle.pmcLink??? PMC1800888
???displayArticle.link??? FEBS Lett
???displayArticle.grants??? [+]

Species referenced: Xenopus laevis
Genes referenced: trpv1

References [+] :
Bailey, Jellyfish envenoming syndromes: unknown toxic mechanisms and unproven therapies. 2003, Pubmed