XB-ART-35502
Trends Cell Biol
2007 Feb 01;172:72-9. doi: 10.1016/j.tcb.2006.12.001.
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HMG chromosomal proteins in development and disease.
Hock R
,
Furusawa T
,
Ueda T
,
Bustin M
.
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The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the chromatin fiber. They are important in chromatin dynamics and influence DNA processing in the context of chromatin. Results emerging from studies of human disease, genetically modified mice and cells with altered HMG expression indicate that the expression of the HMG proteins is developmentally regulated and that changes in HMG protein levels alter the cellular phenotype and can lead to developmental abnormalities and disease. Here, we focus on the biological function of HMG proteins and highlight their possible roles in cellular differentiation and in the etiology of various diseases.
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Z01 BC004496-30 NCI NIH HHS , Z01 BC004496-30 Intramural NIH HHS
Species referenced: Xenopus laevis
Genes referenced: hmga2 hmgb1 hmgn1 hmgn2
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