J Struct Biol 2007 May 01;1582:244-53. doi: 10.1016/j.jsb.2007.04.001.

Looking into live cells with in-cell NMR spectroscopy.

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In-cell NMR spectroscopy has gained recent popularity since it provides means to analyze the conformational and functional properties of proteins inside living cells and at atomic resolution. High-resolution in-cell NMR spectroscopy was originally established in bacterial cells and based on a rationale that relies on protein over-expression and sample analysis within the same cellular environment. Here, we review in-cell NMR approaches in Xenopus laevis oocytes and evaluate potential future applications in other eukaryotic cell types.

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