Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Biomed Opt
2007 Jan 01;126:064021. doi: 10.1117/1.2822904.
Show Gene links
Show Anatomy links
Multimodality optical imaging of embryonic heart microstructure.
Yelin R
,
Yelin D
,
Oh WY
,
Yun SH
,
Boudoux C
,
Vakoc BJ
,
Bouma BE
,
Tearney GJ
.
???displayArticle.abstract???
Study of developmental heart defects requires the visualization of the microstructure and function of the embryonic myocardium, ideally with minimal alterations to the specimen. We demonstrate multiple endogenous contrast optical techniques for imaging the Xenopus laevis tadpoleheart. Each technique provides distinct and complementary imaging capabilities, including: 1. 3-D coherence microscopy with subcellular (1 to 2 microm) resolution in fixed embryos, 2. real-time reflectance confocal microscopy with large penetration depth in vivo, and 3. ultra-high speed (up to 900 frames per second) that enables real-time 4-D high resolution imaging in vivo. These imaging modalities can provide a comprehensive picture of the morphologic and dynamic phenotype of the embryonic heart. The potential of endogenous-contrast optical microscopy is demonstrated for investigation of the teratogenic effects of ethanol. Microstructural abnormalities associated with high levels of ethanol exposure are observed, including compromised heart looping and loss of ventricular trabecular mass.
Anderson,
The optics of human skin.
1981,
Pubmed
Badea,
4-D micro-CT of the mouse heart.
2005,
Pubmed
Beaurepaire,
Full-field optical coherence microscopy.
1998,
Pubmed
Bilotta,
Ethanol exposure alters zebrafish development: a novel model of fetal alcohol syndrome.
2004,
Pubmed
Boneva,
Mortality associated with congenital heart defects in the United States: trends and racial disparities, 1979-1997.
2001,
Pubmed
Boppart,
Investigation of developing embryonic morphology using optical coherence tomography.
1996,
Pubmed
,
Xenbase
Boppart,
Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography.
1997,
Pubmed
,
Xenbase
Boppart,
Optical probes and techniques for molecular contrast enhancement in coherence imaging.
2005,
Pubmed
Boudoux,
Rapid wavelength-swept spectrally encoded confocal microscopy.
2005,
Pubmed
Cavieres,
Genetic and developmental modulation of cardiac deficits in prenatal alcohol exposure.
2000,
Pubmed
Chaudhuri,
Alcohol and the developing fetus--a review.
2000,
Pubmed
Choma,
Sensitivity advantage of swept source and Fourier domain optical coherence tomography.
2003,
Pubmed
Clark,
Transcription factors and congenital heart defects.
2006,
Pubmed
Cudd,
Animal model systems for the study of alcohol teratology.
2005,
Pubmed
Dobrucki,
Molecular imaging. A new approach to nuclear cardiology.
2005,
Pubmed
Dresser,
Teratogenic assessment of four solvents using the Frog Embryo Teratogenesis Assay--Xenopus (FETAX).
1992,
Pubmed
,
Xenbase
Dubois,
Ultrahigh-resolution full-field optical coherence tomography.
2004,
Pubmed
Dubois,
Three-dimensional cellular-level imaging using full-field optical coherence tomography.
2004,
Pubmed
Forouhar,
The embryonic vertebrate heart tube is a dynamic suction pump.
2006,
Pubmed
Hoffman,
Congenital heart disease: incidence and inheritance.
1990,
Pubmed
Hove,
Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis.
2003,
Pubmed
Huber,
Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm.
2005,
Pubmed
Jenkins,
Ultrahigh-speed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier Domain Mode Locked laser.
2007,
Pubmed
Jenkins,
4D embryonic cardiography using gated optical coherence tomography.
2006,
Pubmed
Jones,
Recognition of the fetal alcohol syndrome in early infancy.
1973,
Pubmed
Kolker,
Confocal imaging of early heart development in Xenopus laevis.
2000,
Pubmed
,
Xenbase
Kraitchman,
In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction.
2003,
Pubmed
Liebling,
Four-dimensional cardiac imaging in living embryos via postacquisition synchronization of nongated slice sequences.
2005,
Pubmed
Lohr,
Vertebrate model systems in the study of early heart development: Xenopus and zebrafish.
2000,
Pubmed
,
Xenbase
Luo,
Three-dimensional optical coherence tomography of the embryonic murine cardiovascular system.
2006,
Pubmed
Malyar,
Relationship between arterial diameter and perfused tissue volume in myocardial microcirculation: a micro-CT-based analysis.
2004,
Pubmed
Mariampillai,
Doppler optical cardiogram gated 2D color flow imaging at 1000 fps and 4D in vivo visualization of embryonic heart at 45 fps on a swept source OCT system.
2007,
Pubmed
,
Xenbase
Mohun,
The morphology of heart development in Xenopus laevis.
2000,
Pubmed
,
Xenbase
Mone,
Effects of environmental exposures on the cardiovascular system: prenatal period through adolescence.
2004,
Pubmed
Moneron,
Stroboscopic ultrahigh-resolution full-field optical coherence tomography.
2005,
Pubmed
,
Xenbase
Motz,
Spectral- and frequency-encoded fluorescence imaging.
2005,
Pubmed
Nakatsuji,
Craniofacial malformation in Xenopus laevis tadpoles caused by the exposure of early embryos to ethanol.
1983,
Pubmed
,
Xenbase
Newport,
A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage.
1982,
Pubmed
,
Xenbase
Oh,
Wide Tuning Range Wavelength-Swept Laser With Two Semiconductor Optical Amplifiers.
2005,
Pubmed
Olson,
Gene regulatory networks in the evolution and development of the heart.
2006,
Pubmed
Srinivasan,
Noninvasive, in utero imaging of mouse embryonic heart development with 40-MHz echocardiography.
1998,
Pubmed
Srivastava,
A genetic blueprint for cardiac development.
2000,
Pubmed
Stegger,
Monitoring left ventricular dilation in mice with PET.
2005,
Pubmed
Tearney,
Spectrally encoded confocal microscopy.
1998,
Pubmed
Twal,
Retinoic acid reverses ethanol-induced cardiovascular abnormalities in quail embryos.
1997,
Pubmed
Wang,
Japanese medaka (Oryzias latipes): developmental model for the study of alcohol teratology.
2006,
Pubmed
Wiesmann,
Developmental changes of cardiac function and mass assessed with MRI in neonatal, juvenile, and adult mice.
2000,
Pubmed
Yang,
Molecular contrast optical coherence tomography: a review.
2005,
Pubmed
Yang,
High speed, wide velocity dynamic range Doppler optical coherence tomography (Part II): Imaging in vivo cardiac dynamics of Xenopus laevis.
2003,
Pubmed
,
Xenbase
Yazdanfar,
High resolution imaging of in vivo cardiac dynamics using color Doppler optical coherence tomography.
1997,
Pubmed
,
Xenbase
Yelbuz,
Images in cardiovascular medicine. Time-lapse study with high speed video camera in the early embryonic chick heart to visualize a time window of normal and abnormal heart development.
2002,
Pubmed
Yelbuz,
Optical coherence tomography: a new high-resolution imaging technology to study cardiac development in chick embryos.
2002,
Pubmed
Yelin,
Ethanol exposure affects gene expression in the embryonic organizer and reduces retinoic acid levels.
2005,
Pubmed
,
Xenbase
Yun,
Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting.
2004,
Pubmed
Yun,
High-speed optical frequency-domain imaging.
2003,
Pubmed
