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Proc Natl Acad Sci U S A
2010 Mar 02;1079:4418-23. doi: 10.1073/pnas.0913392107.
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Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae.
Wang G
,
Carey AF
,
Carlson JR
,
Zwiebel LJ
.
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A systematic functional analysis across much of the conventional Anopheles gambiae odorant receptor (AgOR) repertoire was carried out in Xenopus oocytes using two-electrode, voltage-clamp electrophysiology. The resulting data indicate that each AgOR manifests a distinct odor-response profile and tuning breadth. The large diversity of tuning responses ranges from AgORs that are responsive to a single or small number of odorants (specialists) to more broadly tuned receptors (generalists). Several AgORs were identified that respond robustly to a range of human volatiles that may play a critical role in anopheline host selection. AgOR responses were analyzed further by constructing a multidimensional odor space representing the relationships between odorants and AgOR responses. Within this space, the distance between odorants is related to both chemical class and concentration and may correlate with olfactory discrimination. This study provides a comprehensive overview of olfactory coding mechanisms of An. gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases.
Benton,
Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo.
2006, Pubmed
Benton,
Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo.
2006,
Pubmed
Benton,
Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila.
2009,
Pubmed
Bernier,
Chemical analysis of human skin emanations: comparison of volatiles from humans that differ in attraction of Aedes aegypti (Diptera: Culicidae).
2002,
Pubmed
Blackwell,
Electrophysiological investigation of larval water and potential oviposition chemo-attractants for Anopheles gambiae s.s.
2000,
Pubmed
Cook,
The use of push-pull strategies in integrated pest management.
2007,
Pubmed
Cork,
Identification of electrophysiologically-active compounds for the malaria mosquito, Anopheles gambiae, in human sweat extracts.
1996,
Pubmed
Cork,
Olfactory basis of host location by mosquitoes and other haematophagous Diptera.
1996,
Pubmed
Du,
Electroantennogram and oviposition bioassay responses of Culex quinquefasciatus and Culex tarsalis (Diptera: Culicidae) to chemicals in odors from Bermuda grass infusions.
1999,
Pubmed
Grant,
Electrophysiological responses from receptor neurons in mosquito maxillary palp sensilla.
1996,
Pubmed
Hallem,
Coding of odors by a receptor repertoire.
2006,
Pubmed
Hallem,
Insect odor and taste receptors.
2006,
Pubmed
Hallem,
The molecular basis of odor coding in the Drosophila antenna.
2004,
Pubmed
Healy,
Human sweat and 2-oxopentanoic acid elicit a landing response from Anopheles gambiae.
2000,
Pubmed
Hill,
G protein-coupled receptors in Anopheles gambiae.
2002,
Pubmed
Krautwurst,
Identification of ligands for olfactory receptors by functional expression of a receptor library.
1998,
Pubmed
Larsson,
Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction.
2004,
Pubmed
Lu,
Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae.
2007,
Pubmed
Lundin,
Membrane topology of the Drosophila OR83b odorant receptor.
2007,
Pubmed
Ma,
Functional mosaic organization of mouse olfactory receptor neurons.
2000,
Pubmed
Malnic,
Combinatorial receptor codes for odors.
1999,
Pubmed
Nakagawa,
Insect sex-pheromone signals mediated by specific combinations of olfactory receptors.
2005,
Pubmed
,
Xenbase
Qiu,
Olfactory Coding in Antennal Neurons of the Malaria Mosquito, Anopheles gambiae.
2006,
Pubmed
Qiu,
Behavioural and electrophysiological responses of the malaria mosquito Anopheles gambiae Giles sensu stricto (Diptera: Culicidae) to human skin emanations.
2004,
Pubmed
Sato,
Insect olfactory receptors are heteromeric ligand-gated ion channels.
2008,
Pubmed
,
Xenbase
Smallegange,
Synergism between ammonia, lactic acid and carboxylic acids as kairomones in the host-seeking behaviour of the malaria mosquito Anopheles gambiae sensu stricto (Diptera: Culicidae).
2005,
Pubmed
Snow,
The global distribution of clinical episodes of Plasmodium falciparum malaria.
2005,
Pubmed
Takken,
Odor-mediated behavior of Afrotropical malaria mosquitoes.
1999,
Pubmed
Takken,
Chemical ecology of insect vectors: temporal, environmental and physiological aspects.
2005,
Pubmed
Wang,
Two-photon calcium imaging reveals an odor-evoked map of activity in the fly brain.
2003,
Pubmed
Wetzel,
Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system.
2001,
Pubmed
,
Xenbase
Wicher,
Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels.
2008,
Pubmed
Xia,
The molecular and cellular basis of olfactory-driven behavior in Anopheles gambiae larvae.
2008,
Pubmed
,
Xenbase
Zeng,
Analysis of characteristic human female axillary odors: Qualitative comparison to males.
1996,
Pubmed
