Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Biochem J
2004 Mar 01;378Pt 2:693-7. doi: 10.1042/BJ20031414.
Show Gene links
Show Anatomy links
Differences in regulatory properties between human and rat glucokinase regulatory protein.
Brocklehurst KJ
,
Davies RA
,
Agius L
.
???displayArticle.abstract???
The inhibition of glucokinase by rat and Xenopus GKRPs (glucokinase regulatory protein) is well documented. We report a comparison of the effects of human and rat GKRPs on glucokinase activity. Human GKRP is a more potent inhibitor of glucokinase than rat GKRP in the absence of fructose 6-phosphate or sorbitol 6-phosphate, and has a higher affinity for these ligands. However, human and rat GKRPs have similar affinities for fructose 1-phosphate and chloride. Residues that are not conserved between the rodent and human proteins affect both the affinity for fructose 6-phosphate and sorbitol 6-phosphate and the inhibitory potency of GKRP on glucokinase in the absence of these ligands.
Alvarez,
Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brain.
2002, Pubmed
Alvarez,
Evidence that glucokinase regulatory protein is expressed and interacts with glucokinase in rat brain.
2002,
Pubmed
Detheux,
Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigation.
1991,
Pubmed
Hawkins,
Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes.
2002,
Pubmed
Hayward,
Organization of the human glucokinase regulator gene GCKR.
1998,
Pubmed
,
Xenbase
Matschinsky,
Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes.
1990,
Pubmed
Matschinsky,
Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics.
2002,
Pubmed
Mookhtiar,
Heterologous expression and characterization of rat liver glucokinase regulatory protein.
1996,
Pubmed
Moore,
Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults.
2000,
Pubmed
Moore,
Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes.
2001,
Pubmed
Van Schaftingen,
A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate.
1989,
Pubmed
Vandercammen,
The mechanism by which rat liver glucokinase is inhibited by the regulatory protein.
1990,
Pubmed
Vandercammen,
Competitive inhibition of liver glucokinase by its regulatory protein.
1991,
Pubmed
Vandercammen,
Species and tissue distribution of the regulatory protein of glucokinase.
1993,
Pubmed
,
Xenbase
Veiga-Da-Cunha,
Cloning and expression of a Xenopus liver cDNA encoding a fructose-phosphate-insensitive regulatory protein of glucokinase.
1994,
Pubmed
,
Xenbase
Veiga-da-Cunha,
Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians.
2003,
Pubmed
Veiga-da-Cunha,
Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase.
2002,
Pubmed
,
Xenbase
Veiga-da-Cunha,
Effect of mutations on the sensitivity of human beta-cell glucokinase to liver regulatory protein.
1996,
Pubmed
Warner,
Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization.
1995,
Pubmed