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Genes Dev
2012 Jan 15;262:105-9. doi: 10.1101/gad.185280.111.
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Wnt signaling: the β-cat(enin)'s meow.
Bauer M
,
Willert K
.
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In a study in the December 15, 2011, issue of Genes & Development, Valenta and colleagues (pp. 2631-2643) constructed a series of β-catenin mutants that allowed them to separate β-catenin's activity as a mediator of Wnt signaling from its activity as cell adhesion component. In doing so, they uncovered some surprising properties of Wnt signaling.
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