Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Biol Chem
2012 May 04;28719:15923-34. doi: 10.1074/jbc.M111.312413.
Show Gene links
Show Anatomy links
Involvement of polo-like kinase 1 (Plk1) in mitotic arrest by inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 1 (MEK-ERK-RSK1) cascade.
Li R
,
Chen DF
,
Zhou R
,
Jia SN
,
Yang JS
,
Clegg JS
,
Yang WJ
.
???displayArticle.abstract???
Cell division is controlled through cooperation of different kinases. Of these, polo-like kinase 1 (Plk1) and p90 ribosomal S6 kinase 1 (RSK1) play key roles. Plk1 acts as a G(2)/M trigger, and RSK1 promotes G(1) progression. Although previous reports show that Plk1 is suppressed by RSK1 during meiosis in Xenopus oocytes, it is still not clear whether this is the case during mitosis or whether Plk1 counteracts the effects of RSK1. Few animal models are available for the study of controlled and transient cell cycle arrest. Here we show that encysted embryos (cysts) of the primitive crustacean Artemia are ideal for such research because they undergo complete cell cycle arrest when they enter diapause (a state of obligate dormancy). We found that Plk1 suppressed the activity of RSK1 during embryonic mitosis and that Plk1 was inhibited during embryonic diapause and mitotic arrest. In addition, studies on HeLa cells using Plk1 siRNA interference and overexpression showed that phosphorylation of RSK1 increased upon interference and decreased after overexpression, suggesting that Plk1 inhibits RSK1. Taken together, these findings provide insights into the regulation of Plk1 during cell division and Artemia diapause cyst formation and the correlation between the activity of Plk1 and RSK1.
Bahassi,
Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.
2002, Pubmed
Bahassi,
Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.
2002,
Pubmed
Bhatt,
The protein kinase p90 rsk as an essential mediator of cytostatic factor activity.
1999,
Pubmed
,
Xenbase
Chen,
Nuclear localization and regulation of erk- and rsk-encoded protein kinases.
1992,
Pubmed
Clegg,
Nuclear-cytoplasmic translocations of protein p26 during aerobic-anoxic transitions in embryos of Artemia franciscana.
1995,
Pubmed
Coleman,
Cdc2 regulatory factors.
1994,
Pubmed
Crowe,
Stabilization of dry Mammalian cells: lessons from nature.
2005,
Pubmed
Dai,
Determination in oocytes of the reproductive modes for the brine shrimp Artemia parthenogenetica.
2011,
Pubmed
Dai,
Extracellular matrix peptides of Artemia cyst shell participate in protecting encysted embryos from extreme environments.
2011,
Pubmed
Dai,
Involvement of p90 ribosomal S6 kinase in termination of cell cycle arrest during development of Artemia-encysted embryos.
2008,
Pubmed
Dalby,
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.
1998,
Pubmed
Donohue,
Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase.
1995,
Pubmed
Eckerdt,
Polo-like kinases and oncogenesis.
2005,
Pubmed
Elia,
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
2003,
Pubmed
,
Xenbase
Ferrell,
Xenopus oocyte maturation: new lessons from a good egg.
1999,
Pubmed
,
Xenbase
Frödin,
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction.
1999,
Pubmed
,
Xenbase
Gebauer,
Synthesis and function of Mos: the control switch of vertebrate oocyte meiosis.
1997,
Pubmed
,
Xenbase
Golsteyn,
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.
1995,
Pubmed
Gotoh,
The MAP kinase cascade: its role in Xenopus oocytes, eggs and embryos.
1995,
Pubmed
,
Xenbase
Gotoh,
Initiation of Xenopus oocyte maturation by activation of the mitogen-activated protein kinase cascade.
1995,
Pubmed
,
Xenbase
Gross,
Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90Rsk.
1999,
Pubmed
,
Xenbase
Gumireddy,
ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.
2005,
Pubmed
Haccard,
Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase.
1993,
Pubmed
,
Xenbase
Hamanaka,
Polo-like kinase is a cell cycle-regulated kinase activated during mitosis.
1995,
Pubmed
Hanks,
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.
1995,
Pubmed
Inoue,
The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs.
2005,
Pubmed
,
Xenbase
Johnson,
Active and inactive protein kinases: structural basis for regulation.
1996,
Pubmed
Lei,
Plk1 depletion in nontransformed diploid cells activates the DNA-damage checkpoint.
2008,
Pubmed
Liang,
The synthesis of a small heat shock/alpha-crystallin protein in Artemia and its relationship to stress tolerance during development.
1999,
Pubmed
Liby,
Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase.
2001,
Pubmed
Liu,
Polo-like kinase 1 in the life and death of cancer cells.
2003,
Pubmed
,
Xenbase
Ma,
The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB.
2003,
Pubmed
Macůrek,
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
2008,
Pubmed
Nakajo,
Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.
2000,
Pubmed
,
Xenbase
Nambu,
Influence of photoperiod and temperature on reproductive mode in the Brine shrimp, Artemia franciscana.
2004,
Pubmed
Okumura,
Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition.
2002,
Pubmed
Pahlavan,
Characterization of polo-like kinase 1 during meiotic maturation of the mouse oocyte.
2000,
Pubmed
Palmer,
A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1.
1998,
Pubmed
,
Xenbase
Qian,
Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis.
1998,
Pubmed
,
Xenbase
Sagata,
The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs.
1989,
Pubmed
,
Xenbase
Sagata,
What does Mos do in oocytes and somatic cells?
1997,
Pubmed
,
Xenbase
Schmittgen,
Analyzing real-time PCR data by the comparative C(T) method.
2008,
Pubmed
Seki,
Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry.
2008,
Pubmed
,
Xenbase
Simmons,
Identification of an early-growth-response gene encoding a novel putative protein kinase.
1992,
Pubmed
Singh,
Mos and the cell cycle.
1997,
Pubmed
Spänkuch,
Cancer inhibition in nude mice after systemic application of U6 promoter-driven short hairpin RNAs against PLK1.
2004,
Pubmed
Takai,
Polo-like kinases (Plks) and cancer.
2005,
Pubmed
Vempati,
p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals.
2010,
Pubmed
Watanabe,
Independent inactivation of MPF and cytostatic factor (Mos) upon fertilization of Xenopus eggs.
1991,
Pubmed
,
Xenbase
Xie,
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.
2001,
Pubmed
Xie,
Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2.
2002,
Pubmed
Yodmuang,
YHV-protease dsRNA inhibits YHV replication in Penaeus monodon and prevents mortality.
2006,
Pubmed
