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XB-ART-451
Biochem Cell Biol 2006 Apr 01;842:257-62. doi: 10.1139/o06-036.
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Conservation of Pitx1 expression during amphibian limb morphogenesis.

Chang WY , Khosrowshahian F , Wolanski M , Marshall R , McCormick W , Perry S , Crawford MJ .


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In contrast to the pattern of limb emergence in mammals, chicks, and the newt N. viridescens, embryos such as Xenopus laevis and Eleutherodactylus coqui initiate pelvic limb buds before they develop pectoral ones. We studied the expression of Pitx1 in X. laevis and E. coqui to determine if this paired-like homeodomain transcription factor directs differentiation specifically of the hindlimb, or if it directs the second pair of limbs to form, namely the forelimbs. We also undertook to determine if embryonic expression patterns were recapitulated during the regeneration of an amputated limb bud. Pitx1 is expressed in hindlimbs in both X. laevis and E. coqui, and expression is similar in both developing and regenerating limb buds. Expression in hindlimbs is restricted to regions of proliferating mesenchyme.

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Species referenced: Xenopus laevis
Genes referenced: pitx1