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J Neuroimmune Pharmacol
2012 Dec 01;74:725-30. doi: 10.1007/s11481-012-9412-x.
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Wnt/β-catenin and its diverse physiological cell signaling pathways in neurodegenerative and neuropsychiatric disorders.
Al-Harthi L
.
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Wnt signaling is a fundamental pathway in embryogenesis which is evolutionary conserved from metazoans to humans. Much of our understanding of Wnt signaling events emerged from key developmental studies in drosophila, zebra fish, xenopus, and mice. Considerable data now exists on the role of Wnt signaling beyond these developmental processes and in particular its role in health and disease. The focus of this special issue is on Wnt/β-catenin and its diverse physiological cell signaling pathways in neurodegenerative and neuropsychiatric disorders. This special issue is composed of six reviews and two original articles selected to highlight recent advances in the role of Wnt signaling in CNS embryonic development, in adult brain function, in neurodegenerative conditions such as Alzheimer's disease, schizophrenia, NeuroAIDS, and in gliomas. The finding that β-catenin can translocate to the nucleus where it binds to TCF/LEF transcription factors to regulate target gene expression was a seminal observation that linked β-catenin/LEF to T cell development and differentiation. We also provide a nostalgic look on recent advances in role of Wnts in T cell development and maturation. These reviews highlight the extensive body of work in these thematic areas as well as identify knowledge gaps, where appropriate. Understanding Wnt function under healthy and diseased conditions may provide a therapeutic resource, albeit it a challenging one, in diseases where dysfunctional and/or diminished Wnt signaling is a prominent player in the disease process.
Al-Harthi,
Interplay between Wnt/β-catenin signaling and HIV: virologic and biologic consequences in the CNS.
2012, Pubmed
Al-Harthi,
Interplay between Wnt/β-catenin signaling and HIV: virologic and biologic consequences in the CNS.
2012,
Pubmed
Behrens,
Functional interaction of beta-catenin with the transcription factor LEF-1.
1996,
Pubmed
,
Xenbase
Bhanot,
A new member of the frizzled family from Drosophila functions as a Wingless receptor.
1996,
Pubmed
Chairoungdua,
Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling.
2010,
Pubmed
Chen,
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.
2009,
Pubmed
DeCarolis,
Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging.
2008,
Pubmed
Duan,
beta-Catenin activity negatively regulates bacteria-induced inflammation.
2007,
Pubmed
Gendelman,
Change in evolution.
2012,
Pubmed
Graham,
Crystal structure of a beta-catenin/Tcf complex.
2000,
Pubmed
,
Xenbase
Henderson,
Role of β-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics.
2011,
Pubmed
Inestrosa,
Wnt signaling: role in Alzheimer disease and schizophrenia.
2012,
Pubmed
Jin,
Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin.
2008,
Pubmed
Korinek,
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
1997,
Pubmed
Liu,
Enhancement of canonical Wnt/β-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells.
2011,
Pubmed
Lu,
Consistent activation of the β-catenin pathway by Salmonella type-three secretion effector protein AvrA in chronically infected intestine.
2012,
Pubmed
Ma,
β-catenin/TCF-1 pathway in T cell development and differentiation.
2012,
Pubmed
Maguschak,
Beta-catenin is required for memory consolidation.
2008,
Pubmed
Maguschak,
A role for WNT/β-catenin signaling in the neural mechanisms of behavior.
2012,
Pubmed
Mikels,
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
2006,
Pubmed
Mulligan,
Wnt signaling in vertebrate neural development and function.
2012,
Pubmed
Nusse,
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.
1982,
Pubmed
Nusse,
Three decades of Wnts: a personal perspective on how a scientific field developed.
2012,
Pubmed
,
Xenbase
Nüsslein-Volhard,
Mutations affecting segment number and polarity in Drosophila.
1980,
Pubmed
Oishi,
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
2003,
Pubmed
,
Xenbase
Ozawa,
The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.
1989,
Pubmed
Pinson,
An LDL-receptor-related protein mediates Wnt signalling in mice.
2000,
Pubmed
Rampias,
Activation of Wnt signaling pathway by human papillomavirus E6 and E7 oncogenes in HPV16-positive oropharyngeal squamous carcinoma cells.
2010,
Pubmed
Rubinfeld,
Association of the APC gene product with beta-catenin.
1993,
Pubmed
Shackelford,
Epstein-Barr virus activates beta-catenin in type III latently infected B lymphocyte lines: association with deubiquitinating enzymes.
2003,
Pubmed
Shi,
Chronic-pain-associated astrocytic reaction in the spinal cord dorsal horn of human immunodeficiency virus-infected patients.
2012,
Pubmed
Shi,
Nuclear translocation of β-catenin is essential for glioma cell survival.
2012,
Pubmed
Siegfried,
wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate.
1992,
Pubmed
Tamai,
LDL-receptor-related proteins in Wnt signal transduction.
2000,
Pubmed
,
Xenbase
Yang-Snyder,
A frizzled homolog functions in a vertebrate Wnt signaling pathway.
1996,
Pubmed
,
Xenbase
Yoshikawa,
Wnt-mediated axon guidance via the Drosophila Derailed receptor.
2003,
Pubmed
Zhang,
Wnt/beta-catenin signaling in glioma.
2012,
Pubmed
